Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice

R. Haque, Bilal Hafeez, I. Ahmad, S. Parvez, S. Pandey, S. Raisuddin

Research output: Contribution to journalArticle

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Abstract

Cyclophosphamide (CP) is one of the most popular alkylating anticancer drugs in spite of its toxic side effects including immunotoxicity, hematotoxicity, mutagenicity and a host of others. The present study was undertaken to assess the protective effects of total aqueous extract of a medicinal plant, Indian gooseberry (Emblica officinalis Gaertn.) in mice treated with CP. These protective effects were studied on immunological parameters and kidney and liver antioxidants. Plant extract treatment at a dose of 100 mg/kg body weight per os (p.o.) for 10 days resulted in the modulation of these parameters in normal as well as CP (50 mg/kg)-treated animals. Plant extract in particular was very effective in reducing CP-induced suppression of humoral immunity. Plant extract treatment in normal animals modulated certain antioxidants of kidney and liver. In CP-exposed animals, plant pretreatment provided protection to antioxidants of kidney. Not only were the reduced glutathione levels significantly (p<0.001) increased but plant extract treatment resulted in restoration of antioxidant enzymes in CP-treated animals. It is suggested that E. officinalis or its medicinal preparations may prove to be useful as a component of combination therapy in cancer patients under CP treatment regimen.

Original languageEnglish (US)
Pages (from-to)643-650
Number of pages8
JournalHuman and Experimental Toxicology
Volume20
Issue number12
DOIs
StatePublished - Dec 1 2001

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Phyllanthus emblica
Cyclophosphamide
Plant Extracts
Animals
Antioxidants
Kidney
Liver
Ribes
Therapeutics
Poisons
Medicinal Plants
Humoral Immunity
Restoration
Glutathione
Body Weight
Modulation

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. / Haque, R.; Hafeez, Bilal; Ahmad, I.; Parvez, S.; Pandey, S.; Raisuddin, S.

In: Human and Experimental Toxicology, Vol. 20, No. 12, 01.12.2001, p. 643-650.

Research output: Contribution to journalArticle

Haque, R. ; Hafeez, Bilal ; Ahmad, I. ; Parvez, S. ; Pandey, S. ; Raisuddin, S. / Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. In: Human and Experimental Toxicology. 2001 ; Vol. 20, No. 12. pp. 643-650.
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