Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes

Thomas A. Penfound, Edna Y. Chiang, Elwaleed A. Ahmed, James Dale

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent vaccine) or conserved C-repeat (J14 vaccine) M protein epitopes and to determine if combination vaccines resulted in enhanced levels of protection. Our results indicated that the protective efficacy of the type-specific vaccine was significantly greater than that of J14 and that the addition of J14 to vaccine formulations did not enhance the level of protection achieved with type-specific formulations.

Original languageEnglish (US)
Pages (from-to)5017-5022
Number of pages6
JournalVaccine
Volume28
Issue number31
DOIs
StatePublished - Jul 1 2010

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Streptococcal Vaccines
epitopes
Epitopes
Vaccines
vaccines
Proteins
proteins
Immunity
Combined Vaccines
cross immunity
serotypes
immunity

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes. / Penfound, Thomas A.; Chiang, Edna Y.; Ahmed, Elwaleed A.; Dale, James.

In: Vaccine, Vol. 28, No. 31, 01.07.2010, p. 5017-5022.

Research output: Contribution to journalArticle

Penfound, Thomas A. ; Chiang, Edna Y. ; Ahmed, Elwaleed A. ; Dale, James. / Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes. In: Vaccine. 2010 ; Vol. 28, No. 31. pp. 5017-5022.
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