Pseudohyponatremia in acute liver disease

Hieu Vo, Aidar R. Gosmanov, Melinda Garcia-Rosell, Barry Wall

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Pseudohyponatremia secondary to hypercholesterolemia is a rare condition. In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed jaundice due to biopsy-confirmed intrahepatic cholestasis and severe hyponatremia, as measured by indirect potentiometry. She was initially intensively treated for hyponatremia. Additional evaluation identified severe hypercholesterolemia, occurring in the absence of lipemic serum. Lipoprotein analysis was consistent with lipoprotein X. Measurement of plasma osmolality and serum sodium concentration using direct potentiometry confirmed the presence of pseudohyponatremia. With supportive care, cholestasis and associated jaundice resolved leading to resolution of both hypercholesterolemia and pseudohyponatremia.

Original languageEnglish (US)
Pages (from-to)62-64
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume345
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Acute Disease
Hypercholesterolemia
Potentiometry
Liver Diseases
Hyponatremia
Jaundice
Lipoprotein-X
Sodium
Serum
Intrahepatic Cholestasis
Cholestasis
Virus Diseases
Hepacivirus
Osmolar Concentration
Lipoproteins
Cholesterol
Biopsy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Pseudohyponatremia in acute liver disease. / Vo, Hieu; Gosmanov, Aidar R.; Garcia-Rosell, Melinda; Wall, Barry.

In: American Journal of the Medical Sciences, Vol. 345, No. 1, 01.01.2013, p. 62-64.

Research output: Contribution to journalArticle

Vo, Hieu ; Gosmanov, Aidar R. ; Garcia-Rosell, Melinda ; Wall, Barry. / Pseudohyponatremia in acute liver disease. In: American Journal of the Medical Sciences. 2013 ; Vol. 345, No. 1. pp. 62-64.
@article{e7cb67a384624d819393e8b5cf1b3b15,
title = "Pseudohyponatremia in acute liver disease",
abstract = "Pseudohyponatremia secondary to hypercholesterolemia is a rare condition. In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed jaundice due to biopsy-confirmed intrahepatic cholestasis and severe hyponatremia, as measured by indirect potentiometry. She was initially intensively treated for hyponatremia. Additional evaluation identified severe hypercholesterolemia, occurring in the absence of lipemic serum. Lipoprotein analysis was consistent with lipoprotein X. Measurement of plasma osmolality and serum sodium concentration using direct potentiometry confirmed the presence of pseudohyponatremia. With supportive care, cholestasis and associated jaundice resolved leading to resolution of both hypercholesterolemia and pseudohyponatremia.",
author = "Hieu Vo and Gosmanov, {Aidar R.} and Melinda Garcia-Rosell and Barry Wall",
year = "2013",
month = "1",
day = "1",
doi = "10.1097/MAJ.0b013e3182703327",
language = "English (US)",
volume = "345",
pages = "62--64",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Pseudohyponatremia in acute liver disease

AU - Vo, Hieu

AU - Gosmanov, Aidar R.

AU - Garcia-Rosell, Melinda

AU - Wall, Barry

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Pseudohyponatremia secondary to hypercholesterolemia is a rare condition. In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed jaundice due to biopsy-confirmed intrahepatic cholestasis and severe hyponatremia, as measured by indirect potentiometry. She was initially intensively treated for hyponatremia. Additional evaluation identified severe hypercholesterolemia, occurring in the absence of lipemic serum. Lipoprotein analysis was consistent with lipoprotein X. Measurement of plasma osmolality and serum sodium concentration using direct potentiometry confirmed the presence of pseudohyponatremia. With supportive care, cholestasis and associated jaundice resolved leading to resolution of both hypercholesterolemia and pseudohyponatremia.

AB - Pseudohyponatremia secondary to hypercholesterolemia is a rare condition. In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed jaundice due to biopsy-confirmed intrahepatic cholestasis and severe hyponatremia, as measured by indirect potentiometry. She was initially intensively treated for hyponatremia. Additional evaluation identified severe hypercholesterolemia, occurring in the absence of lipemic serum. Lipoprotein analysis was consistent with lipoprotein X. Measurement of plasma osmolality and serum sodium concentration using direct potentiometry confirmed the presence of pseudohyponatremia. With supportive care, cholestasis and associated jaundice resolved leading to resolution of both hypercholesterolemia and pseudohyponatremia.

UR - http://www.scopus.com/inward/record.url?scp=84871972447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871972447&partnerID=8YFLogxK

U2 - 10.1097/MAJ.0b013e3182703327

DO - 10.1097/MAJ.0b013e3182703327

M3 - Article

VL - 345

SP - 62

EP - 64

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 1

ER -