Psychiatric applications of bromocriptine therapy

P. A. Sitland-Marken, B. G. Wells, J. H. Froemming, C. C. Chu, Candace Brown

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

Bromocriptine, an ergot alkaloid derivative that possesses both dopamine agonist and antagonist activity, has been studied in a broad spectrum of psychiatric illnesses. The literature consists primarily of case reports and small trials limited by methodological shortcomings. The authors critically review these reports, focusing on efficacy, mechanistic issues, dosing, side effects, predictors of response, monitoring parameters, and practical guidelines. Preliminary data suggest bromocriptine may have promise in the treatment of neuroleptic malignant syndrome, cocaine withdrawal, and depression. At present, the agent appears less efficacious in the treatment of tardive dyskinesia, mania, and schizophrenia; however, doses in these trials may have been excessive, producing primarily postsynaptic agonist effects. More extensive clinical trials are required to clearly define the role of bromocriptine in psychiatry.

Original languageEnglish (US)
Pages (from-to)68-82
Number of pages15
JournalJournal of Clinical Psychiatry
Volume51
Issue number2
StatePublished - Jan 1 1990

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Bromocriptine
Psychiatry
Ergot Alkaloids
Neuroleptic Malignant Syndrome
Dopamine Antagonists
Dopamine Agonists
Bipolar Disorder
Cocaine
Schizophrenia
Therapeutics
Clinical Trials
Guidelines
Depression

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Sitland-Marken, P. A., Wells, B. G., Froemming, J. H., Chu, C. C., & Brown, C. (1990). Psychiatric applications of bromocriptine therapy. Journal of Clinical Psychiatry, 51(2), 68-82.

Psychiatric applications of bromocriptine therapy. / Sitland-Marken, P. A.; Wells, B. G.; Froemming, J. H.; Chu, C. C.; Brown, Candace.

In: Journal of Clinical Psychiatry, Vol. 51, No. 2, 01.01.1990, p. 68-82.

Research output: Contribution to journalReview article

Sitland-Marken, PA, Wells, BG, Froemming, JH, Chu, CC & Brown, C 1990, 'Psychiatric applications of bromocriptine therapy', Journal of Clinical Psychiatry, vol. 51, no. 2, pp. 68-82.
Sitland-Marken PA, Wells BG, Froemming JH, Chu CC, Brown C. Psychiatric applications of bromocriptine therapy. Journal of Clinical Psychiatry. 1990 Jan 1;51(2):68-82.
Sitland-Marken, P. A. ; Wells, B. G. ; Froemming, J. H. ; Chu, C. C. ; Brown, Candace. / Psychiatric applications of bromocriptine therapy. In: Journal of Clinical Psychiatry. 1990 ; Vol. 51, No. 2. pp. 68-82.
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