Psychosis as presenting symptom in adult-onset Hallervorden-Spatz syndrome

Marios Panas, Konstantinos Spengos, Georgios Koutsis, Georgios Tsivgoulis, Konstantinos Sfagos, Nikolaos Kalfakis, Dimitris Vassilopoulos

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Hallervorden-Spatz syndrome is characterized by pyramidal and extrapyramidal signs, and dysarthria and dementia. Psychiatric symptomatology can emerge in the course of the disorder. Mutations in the pantothenate kinase 2 gene have been found in many cases. We report a case with psychosis as sole presenting symptom. Case: A 41-year-old man presented with change in behavior and paranoid delusional ideation. Six months later, spasticity, extrapyramidal rigidity and dysarthria were added to the picture. Eventually, the patient became mute and wheel-chair bound. The brain magnetic resonance imaging (MRI) was consistent with iron depositions in the globus pallidus and substantia nigra. Conclusions: In this case, the combination of clinical and MRI findings was consistent with Hallervorden-Spatz syndrome. The combination of psychiatric and MRI findings should lead to further neurological investigation.

Original languageEnglish (US)
Pages (from-to)122-124
Number of pages3
JournalActa Neuropsychiatrica
Volume19
Issue number2
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

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Pantothenate Kinase-Associated Neurodegeneration
Psychotic Disorders
Dysarthria
Magnetic Resonance Imaging
Paranoid Behavior
Psychiatry
Muscle Rigidity
Wheelchairs
Globus Pallidus
Substantia Nigra
Dementia
Iron
Mutation
Brain
Genes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Panas, M., Spengos, K., Koutsis, G., Tsivgoulis, G., Sfagos, K., Kalfakis, N., & Vassilopoulos, D. (2007). Psychosis as presenting symptom in adult-onset Hallervorden-Spatz syndrome. Acta Neuropsychiatrica, 19(2), 122-124. https://doi.org/10.1111/j.1601-5215.2006.00163.x

Psychosis as presenting symptom in adult-onset Hallervorden-Spatz syndrome. / Panas, Marios; Spengos, Konstantinos; Koutsis, Georgios; Tsivgoulis, Georgios; Sfagos, Konstantinos; Kalfakis, Nikolaos; Vassilopoulos, Dimitris.

In: Acta Neuropsychiatrica, Vol. 19, No. 2, 01.01.2007, p. 122-124.

Research output: Contribution to journalArticle

Panas, M, Spengos, K, Koutsis, G, Tsivgoulis, G, Sfagos, K, Kalfakis, N & Vassilopoulos, D 2007, 'Psychosis as presenting symptom in adult-onset Hallervorden-Spatz syndrome', Acta Neuropsychiatrica, vol. 19, no. 2, pp. 122-124. https://doi.org/10.1111/j.1601-5215.2006.00163.x
Panas, Marios ; Spengos, Konstantinos ; Koutsis, Georgios ; Tsivgoulis, Georgios ; Sfagos, Konstantinos ; Kalfakis, Nikolaos ; Vassilopoulos, Dimitris. / Psychosis as presenting symptom in adult-onset Hallervorden-Spatz syndrome. In: Acta Neuropsychiatrica. 2007 ; Vol. 19, No. 2. pp. 122-124.
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