Pulmonary and systemic vascular effects of exogenous prostaglandin I2 in fetal lambs

Charles Leffler, Jack R. Hessler

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Effects of PGI2 upon pulmonary vascular resistance and systemic arterial pressure of near term features were evaluated in anesthetized, exteriorized, unventilated fetal lambs by means of an open-chest, pump-perfused lung preparation. These effects were compared to those of PGE1 and PGE2 in the same animals. Intrapulmonary arterial infusions of PGI2 produced dose-dependent decreases in pulmonary vascular resistance and systemic arterial pressure. Effects of PGI2 upon pulmonary vascular resistance are intermediate with respect to those of PGE1 (greater) and PGE2 (less). PGI2 is a potent hypotensive compound when administered to fetal lambs, producing dose-dependent decreases in systemic arterial pressure. When the three prostaglandin are infused into the pulmonary artery, effects on systemic arterial pressure of PGE1 and PGI2 are nearly identical. Effects of PGE2 are considerably less. PGI2 is a potent dilator of fetal lamb vessels and could play a role in circulatory control during perinatal transition.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalEuropean Journal of Pharmacology
Volume54
Issue number1-2
DOIs
StatePublished - Feb 15 1979

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Epoprostenol
Blood Vessels
Lung
Alprostadil
Arterial Pressure
Dinoprostone
Vascular Resistance
Pulmonary Artery
Prostaglandins
Thorax

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Pulmonary and systemic vascular effects of exogenous prostaglandin I2 in fetal lambs. / Leffler, Charles; Hessler, Jack R.

In: European Journal of Pharmacology, Vol. 54, No. 1-2, 15.02.1979, p. 37-42.

Research output: Contribution to journalArticle

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