Pulmonary Kaposi's sarcoma in the acquired immune deficiency syndrome. Clinical, radiographic, and pathologic manifestations

Gianfranco Meduri, Diane E. Stover, Marjorie Lee, Patricia L. Myskowski, James F. Caravelli, Muhammad B. Zaman

Research output: Contribution to journalArticle

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Abstract

Pulmonary Kaposl's sarcoma related to the acquired Immune deficiency syndrome (AIDS) has not been well characterized. To define the clinical, radiographic, and pathologic features of this entity, 11 autopsy-proved cases of pulmonary Kaposi's sarcoma were reviewed. The most common clinical symptoms were dyspnea and cough, but hemoptysis and stridor were also found. Nodular Infiltrates and pleural effusions were the most commonly found radiographic abnormalities. Pulmonary function tests were sensitive in detecting the pulmonary abnormalities due to Kaposl's sarcoma. A low diffusion capacity, lack of arterial desaturation with exercise, and obstruction to airflow were suggestive of pulmonary involvement with this malignancy. Although endobronchial Kaposi's sarcoma was visualized at bronchoscopy as cherry-red, slightly raised lesions, bronchial biopsy specimens always showed no abnormalities. Transbronchial brushings and biopsy specimens and analysis of pleural fluid were also not helpful in establishing a diagnosis. In the seven subjects with extensive parenchymal Kaposl's sarcoma at autopsy, the pleura was always involved. Eight subjects had involvement of the tracheobronchial tree. In all of the subjects, pulmonary Kaposl's sarcoma was a significant cause of morbidity, and in three of 11 subjects (27 percent) it was the direct cause of death.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalThe American Journal of Medicine
Volume81
Issue number1
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Kaposi's Sarcoma
Acquired Immunodeficiency Syndrome
Sarcoma
Lung
Autopsy
Biopsy
Hemoptysis
Pleura
Respiratory Function Tests
Respiratory Sounds
Bronchoscopy
Pleural Effusion
Cough
Dyspnea
Cause of Death
Morbidity
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Pulmonary Kaposi's sarcoma in the acquired immune deficiency syndrome. Clinical, radiographic, and pathologic manifestations. / Meduri, Gianfranco; Stover, Diane E.; Lee, Marjorie; Myskowski, Patricia L.; Caravelli, James F.; Zaman, Muhammad B.

In: The American Journal of Medicine, Vol. 81, No. 1, 01.01.1986, p. 11-18.

Research output: Contribution to journalArticle

Meduri, Gianfranco ; Stover, Diane E. ; Lee, Marjorie ; Myskowski, Patricia L. ; Caravelli, James F. ; Zaman, Muhammad B. / Pulmonary Kaposi's sarcoma in the acquired immune deficiency syndrome. Clinical, radiographic, and pathologic manifestations. In: The American Journal of Medicine. 1986 ; Vol. 81, No. 1. pp. 11-18.
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