Pulmonary Vascular Responses of Newborn Goats to Aerosolized Prostaglandin E1

Charles Leffler, T. Tyler, S. Cassin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Effects of aerosolized prosta-glandin E1 (PGE1) on pulmonary vascular resistance, systemic arterial pressure, and heart rate of anesthetized newborn goats were evaluated in situ during normoxia and hypoxia by means of an open-chest, pump-perfused lung preparation. Pulmonary vascular resistance, systemic arterial pressure, and heart rate were reduced during 10-min administration of PGE1 aerosols. PGE1 aerosols produced small effects on pulmonary vascular resistance and pronounced effects on systemic arterial pressure. The effect of PGE1 on systemic arterial pressure was not different whether administered as an aerosol or infused directly into the left ventricle. PGE1 infused into left pulmonary arterial blood has a greater effect on pulmonary vascular resistance and less effect on systemic arterial pressure than PGE1 administered as an aerosol. We acknowledge the excellent technical assistance of N. L. Murtha, L. Tumarkin, J. Howard, and P. Eitzman. The aid of D. Dessautels in selecting a nebulizer is greatly appreciated. We would like also to thank Drs. A. Otis and M. Jaeger for critically reading the manuscript.

Original languageEnglish (US)
Pages (from-to)19-22
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume155
Issue number1
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

Fingerprint

Alprostadil
Goats
Blood Vessels
Arterial Pressure
Aerosols
Vascular Resistance
Lung
Heart Rate
Manuscripts
Nebulizers and Vaporizers
Heart Ventricles
Reading
Blood
Thorax
Pumps

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pulmonary Vascular Responses of Newborn Goats to Aerosolized Prostaglandin E1 . / Leffler, Charles; Tyler, T.; Cassin, S.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 155, No. 1, 01.01.1977, p. 19-22.

Research output: Contribution to journalArticle

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