Pulse wave velocity and age- and gender-dependent aortic wall hardening in fowl

Ciro A. Ruiz-Feria, Yimu Yang, Donald Thomason, Jarred White, Guibin Su, Hiroko Nishimura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Before sexual maturation, chickens (Gallus gallus) show high blood pressure (BP) and neointimal plaques in the lower abdominal aortae (AbA). We investigated age/sex-related changes in pulse wave velocity (PWV), elastin, collagen, and protein levels in AbA, and cardiac morphology to determine whether PWV increases during incremental increases in BP of maturing fowl, while arterial stiffness becomes dominant with aging. PWV (m/s) was significantly greater in male chicks (6-7 weeks, 9.3 ± 0.8; females, 6.1 ± 0.5) and remained high in cockerels (13 weeks), young (27-28 weeks), and adults (44-66 weeks). PWV increased in prepubertal pullets (10.0 ± 0.9), dropped significantly in young hens, and remained low in adults. In contrast, medial thickness, protein levels, and collagen levels increased, while elastin/collagen ratios decreased, with maturation/aging. Males had heavier ventricular mass and thicker ventricular walls than females at all ages; left ventricular thickness decreased with maturation/aging. Thus, sustained high BP may have caused progressive medial hypertrophy, increased aortic rigidity, and enlarged hearts with left ventricular dilation. PWV of AbA was already greater in male chicks at an age when both sexes have similar collagen levels and low protein levels, suggesting that a factor other than structural stiffness may be an important determinant of PWV.

Original languageEnglish (US)
Pages (from-to)429-436
Number of pages8
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume154
Issue number4
DOIs
StatePublished - Dec 1 2009

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Pulse Wave Analysis
Hardening
Abdominal Aorta
Blood pressure
Collagen
Elastin
Aging of materials
Chickens
Stiffness
Hypertension
Sexual Maturation
Vascular Stiffness
Proteins
Cardiomegaly
Rigidity
Hypertrophy
Dilatation
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology

Cite this

Pulse wave velocity and age- and gender-dependent aortic wall hardening in fowl. / Ruiz-Feria, Ciro A.; Yang, Yimu; Thomason, Donald; White, Jarred; Su, Guibin; Nishimura, Hiroko.

In: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, Vol. 154, No. 4, 01.12.2009, p. 429-436.

Research output: Contribution to journalArticle

Ruiz-Feria, Ciro A. ; Yang, Yimu ; Thomason, Donald ; White, Jarred ; Su, Guibin ; Nishimura, Hiroko. / Pulse wave velocity and age- and gender-dependent aortic wall hardening in fowl. In: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 2009 ; Vol. 154, No. 4. pp. 429-436.
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