Pyelonephritis in pregnancy

Once-a-day ceftriaxone versus multiple doses of cefazolin. A randomized, double-blind trial

Luis Sanchez-Ramos, Kenneth J. McAlpine, Charles Adair, Andrew M. Kaunitz, Isaac Delke, Donna K. Briones

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to compare the efficacy of a single daily dose of intravenous ceftriaxone with that of multiple-dose cefazolin in the treatment of acute pyelonephritis in pregnancy. STUDY DESIGN: This was a double-blind, randomized, clinical trial. Patients admitted to the hospital with the diagnosis of acute pyelonephritis in pregnancy were enrolled and randomized according to a computer-generated randomization schedule. The study group received a single daily 1 gm dose of ceftriazone intravenously along with two additional doses of normal saline solution. The comparison group received three daily 2 gm doses of cefazolin intravenously. All infusions were given on an 8-hour schedule. Treatments were continued until the patient became afebrile. Each patient was discharged from the hospital on a regimen of appropriate oral antibiotics as directed by urine culture and sensitivities. At follow-up visits test-of-cure cultures were obtained. RESULTS: During the 2 year study period, 178 patients were randomized: 88 received cefazolin and 90 ceftriazone. Patient demographics and presenting signs and symptoms were similar in both groups. No differences were noted between the groups regarding days of febrile morbidity, length of hospital stay, or treatment failures. CONCLUSIONS: Daily single-dose intravenous ceftriazone is as effective as multiple-dose cefazolin in the treatment of patients with acute pyelonephritis during pregnancy.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume172
Issue number1 PART 1
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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Cefazolin
Ceftriaxone
Pyelonephritis
Pregnancy
Length of Stay
Appointments and Schedules
Random Allocation
Treatment Failure
Sodium Chloride
Signs and Symptoms
Fever
Therapeutics
Randomized Controlled Trials
Demography
Urine
Anti-Bacterial Agents
Morbidity

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Pyelonephritis in pregnancy : Once-a-day ceftriaxone versus multiple doses of cefazolin. A randomized, double-blind trial. / Sanchez-Ramos, Luis; McAlpine, Kenneth J.; Adair, Charles; Kaunitz, Andrew M.; Delke, Isaac; Briones, Donna K.

In: American Journal of Obstetrics and Gynecology, Vol. 172, No. 1 PART 1, 01.01.1995, p. 129-133.

Research output: Contribution to journalArticle

Sanchez-Ramos, Luis ; McAlpine, Kenneth J. ; Adair, Charles ; Kaunitz, Andrew M. ; Delke, Isaac ; Briones, Donna K. / Pyelonephritis in pregnancy : Once-a-day ceftriaxone versus multiple doses of cefazolin. A randomized, double-blind trial. In: American Journal of Obstetrics and Gynecology. 1995 ; Vol. 172, No. 1 PART 1. pp. 129-133.
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