QDR 4500A dual-energy X-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults

Dale A. Schoeller, Frances Tylavsky, David J. Baer, William C. Chumlea, Carrie P. Earthman, Thomas Fuerst, Tamara B. Harris, Steven B. Heymsfield, Mary Horlick, Timothy G. Lohman, Henry C. Lukaski, John Shepherd, Roger M. Siervogel, Lori G. Borrud

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Abstract

Background: Dual-energy X-ray absorptiometry (DXA) has become one of the most frequently used methods for estimating human body composition. Although the DXA technique has been validated for the measurement of fat-free mass and fat mass, differences in calibration between instruments produced by different manufacturers, as well as between different models produced by the same manufacturer, have been reported. Objective: The objective was to compare the calibration of the QDR 4500A against criterion methods in a large heterogeneous population. Design: DXA-derived body-composition data were obtained from 7 studies: 6 data sets were provided by the investigators, one of which was published. The data included fat mass and fat-free mass measured with a QDR 4500A and criteria measurements of body composition from total body water by dilution at 4 centers, densitometry from 1 center, and four-compartment analysis at 2 centers. Results: In the cohort of 1195 subjects, 602 men and 593 women aged 19-82 y with a body mass index (in kg/m2) of 16-44, the fan-beam DXA overestimated fat-free mass (P < 0.05). A significant difference was observed in all 7 data sets, and the mean (±SE) was 5 ± 1%. Conclusions: It is recommended that the lean soft tissue mass estimate with the fan-beam QDR 4500A be reduced by 5% and that for fat mass be increased by that same mass. This finding is particularly important because the National Health and Nutrition Examination Survey is using the QDR 4500A to assess body composition in a nationally representative sample of persons in the United States.

Original languageEnglish (US)
Pages (from-to)1018-1025
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume81
Issue number5
StatePublished - Dec 12 2005

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Fats
Photon Absorptiometry
X-Rays
Body Composition
Calibration
Densitometry
Body Water
Nutrition Surveys
Human Body
Body Mass Index
Research Personnel
Population
Datasets

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Schoeller, D. A., Tylavsky, F., Baer, D. J., Chumlea, W. C., Earthman, C. P., Fuerst, T., ... Borrud, L. G. (2005). QDR 4500A dual-energy X-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults. American Journal of Clinical Nutrition, 81(5), 1018-1025.

QDR 4500A dual-energy X-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults. / Schoeller, Dale A.; Tylavsky, Frances; Baer, David J.; Chumlea, William C.; Earthman, Carrie P.; Fuerst, Thomas; Harris, Tamara B.; Heymsfield, Steven B.; Horlick, Mary; Lohman, Timothy G.; Lukaski, Henry C.; Shepherd, John; Siervogel, Roger M.; Borrud, Lori G.

In: American Journal of Clinical Nutrition, Vol. 81, No. 5, 12.12.2005, p. 1018-1025.

Research output: Contribution to journalArticle

Schoeller, DA, Tylavsky, F, Baer, DJ, Chumlea, WC, Earthman, CP, Fuerst, T, Harris, TB, Heymsfield, SB, Horlick, M, Lohman, TG, Lukaski, HC, Shepherd, J, Siervogel, RM & Borrud, LG 2005, 'QDR 4500A dual-energy X-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults', American Journal of Clinical Nutrition, vol. 81, no. 5, pp. 1018-1025.
Schoeller, Dale A. ; Tylavsky, Frances ; Baer, David J. ; Chumlea, William C. ; Earthman, Carrie P. ; Fuerst, Thomas ; Harris, Tamara B. ; Heymsfield, Steven B. ; Horlick, Mary ; Lohman, Timothy G. ; Lukaski, Henry C. ; Shepherd, John ; Siervogel, Roger M. ; Borrud, Lori G. / QDR 4500A dual-energy X-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults. In: American Journal of Clinical Nutrition. 2005 ; Vol. 81, No. 5. pp. 1018-1025.
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abstract = "Background: Dual-energy X-ray absorptiometry (DXA) has become one of the most frequently used methods for estimating human body composition. Although the DXA technique has been validated for the measurement of fat-free mass and fat mass, differences in calibration between instruments produced by different manufacturers, as well as between different models produced by the same manufacturer, have been reported. Objective: The objective was to compare the calibration of the QDR 4500A against criterion methods in a large heterogeneous population. Design: DXA-derived body-composition data were obtained from 7 studies: 6 data sets were provided by the investigators, one of which was published. The data included fat mass and fat-free mass measured with a QDR 4500A and criteria measurements of body composition from total body water by dilution at 4 centers, densitometry from 1 center, and four-compartment analysis at 2 centers. Results: In the cohort of 1195 subjects, 602 men and 593 women aged 19-82 y with a body mass index (in kg/m2) of 16-44, the fan-beam DXA overestimated fat-free mass (P < 0.05). A significant difference was observed in all 7 data sets, and the mean (±SE) was 5 ± 1{\%}. Conclusions: It is recommended that the lean soft tissue mass estimate with the fan-beam QDR 4500A be reduced by 5{\%} and that for fat mass be increased by that same mass. This finding is particularly important because the National Health and Nutrition Examination Survey is using the QDR 4500A to assess body composition in a nationally representative sample of persons in the United States.",
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AU - Schoeller, Dale A.

AU - Tylavsky, Frances

AU - Baer, David J.

AU - Chumlea, William C.

AU - Earthman, Carrie P.

AU - Fuerst, Thomas

AU - Harris, Tamara B.

AU - Heymsfield, Steven B.

AU - Horlick, Mary

AU - Lohman, Timothy G.

AU - Lukaski, Henry C.

AU - Shepherd, John

AU - Siervogel, Roger M.

AU - Borrud, Lori G.

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N2 - Background: Dual-energy X-ray absorptiometry (DXA) has become one of the most frequently used methods for estimating human body composition. Although the DXA technique has been validated for the measurement of fat-free mass and fat mass, differences in calibration between instruments produced by different manufacturers, as well as between different models produced by the same manufacturer, have been reported. Objective: The objective was to compare the calibration of the QDR 4500A against criterion methods in a large heterogeneous population. Design: DXA-derived body-composition data were obtained from 7 studies: 6 data sets were provided by the investigators, one of which was published. The data included fat mass and fat-free mass measured with a QDR 4500A and criteria measurements of body composition from total body water by dilution at 4 centers, densitometry from 1 center, and four-compartment analysis at 2 centers. Results: In the cohort of 1195 subjects, 602 men and 593 women aged 19-82 y with a body mass index (in kg/m2) of 16-44, the fan-beam DXA overestimated fat-free mass (P < 0.05). A significant difference was observed in all 7 data sets, and the mean (±SE) was 5 ± 1%. Conclusions: It is recommended that the lean soft tissue mass estimate with the fan-beam QDR 4500A be reduced by 5% and that for fat mass be increased by that same mass. This finding is particularly important because the National Health and Nutrition Examination Survey is using the QDR 4500A to assess body composition in a nationally representative sample of persons in the United States.

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