Quantifying the extent of invasive carcinoma and margin status in partial mastectomy cases having a gross lesion

Is a defined tissue processing protocol needed?

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Accurate estimation of disease extent and margin status is critical when evaluating partial mastectomy cases because both are predictors of recurrence. No published standards exist for processing specimens involved by invasive carcinoma, presumably because such cases have a gross lesion. We retrospectively studied 100 partial mastectomy cases and concluded that a standardized tissue mapping protocol is needed to ensure adequate pathologic examination even when a gross lesion is present. When mapped and unmapped findings were compared, 17 cases (10 with ductal and 7 with lobular carcinoma) had an increase in carcinoma size, 12 cases (9 with ductal and 3 with lobular carcinoma) had an increase in pathologic T stage, and positive margins were found in 8 cases (7 with ductal and 1 with lobular carcinoma). We describe our tissue-mapping protocol, and advocate its use as a standardized protocol for processing all partial mastectomy specimens.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume136
Issue number5
DOIs
StatePublished - Nov 1 2011

Fingerprint

Lobular Carcinoma
Segmental Mastectomy
Carcinoma
Recurrence

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

@article{d3c146e5b8ba48a7ba67664cb58d4c96,
title = "Quantifying the extent of invasive carcinoma and margin status in partial mastectomy cases having a gross lesion: Is a defined tissue processing protocol needed?",
abstract = "Accurate estimation of disease extent and margin status is critical when evaluating partial mastectomy cases because both are predictors of recurrence. No published standards exist for processing specimens involved by invasive carcinoma, presumably because such cases have a gross lesion. We retrospectively studied 100 partial mastectomy cases and concluded that a standardized tissue mapping protocol is needed to ensure adequate pathologic examination even when a gross lesion is present. When mapped and unmapped findings were compared, 17 cases (10 with ductal and 7 with lobular carcinoma) had an increase in carcinoma size, 12 cases (9 with ductal and 3 with lobular carcinoma) had an increase in pathologic T stage, and positive margins were found in 8 cases (7 with ductal and 1 with lobular carcinoma). We describe our tissue-mapping protocol, and advocate its use as a standardized protocol for processing all partial mastectomy specimens.",
author = "George Sneed and Lisa Duncan",
year = "2011",
month = "11",
day = "1",
doi = "10.1309/AJCPY4MI1RCWPTVR",
language = "English (US)",
volume = "136",
pages = "747--753",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "5",

}

TY - JOUR

T1 - Quantifying the extent of invasive carcinoma and margin status in partial mastectomy cases having a gross lesion

T2 - Is a defined tissue processing protocol needed?

AU - Sneed, George

AU - Duncan, Lisa

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Accurate estimation of disease extent and margin status is critical when evaluating partial mastectomy cases because both are predictors of recurrence. No published standards exist for processing specimens involved by invasive carcinoma, presumably because such cases have a gross lesion. We retrospectively studied 100 partial mastectomy cases and concluded that a standardized tissue mapping protocol is needed to ensure adequate pathologic examination even when a gross lesion is present. When mapped and unmapped findings were compared, 17 cases (10 with ductal and 7 with lobular carcinoma) had an increase in carcinoma size, 12 cases (9 with ductal and 3 with lobular carcinoma) had an increase in pathologic T stage, and positive margins were found in 8 cases (7 with ductal and 1 with lobular carcinoma). We describe our tissue-mapping protocol, and advocate its use as a standardized protocol for processing all partial mastectomy specimens.

AB - Accurate estimation of disease extent and margin status is critical when evaluating partial mastectomy cases because both are predictors of recurrence. No published standards exist for processing specimens involved by invasive carcinoma, presumably because such cases have a gross lesion. We retrospectively studied 100 partial mastectomy cases and concluded that a standardized tissue mapping protocol is needed to ensure adequate pathologic examination even when a gross lesion is present. When mapped and unmapped findings were compared, 17 cases (10 with ductal and 7 with lobular carcinoma) had an increase in carcinoma size, 12 cases (9 with ductal and 3 with lobular carcinoma) had an increase in pathologic T stage, and positive margins were found in 8 cases (7 with ductal and 1 with lobular carcinoma). We describe our tissue-mapping protocol, and advocate its use as a standardized protocol for processing all partial mastectomy specimens.

UR - http://www.scopus.com/inward/record.url?scp=80355125728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80355125728&partnerID=8YFLogxK

U2 - 10.1309/AJCPY4MI1RCWPTVR

DO - 10.1309/AJCPY4MI1RCWPTVR

M3 - Article

VL - 136

SP - 747

EP - 753

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 5

ER -