Quantitative effects of palivizumab and donor-derived T cells on chronic respiratory syncytial virus infection, lung disease, and fusion glycoprotein amino acid sequences in a patient before and after bone marrow transplantation.

C. M. El Saleeby, J. Suzich, M. E. Conley, John Devincenzo

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A patient with respiratory syncytial virus (RSV) infection and severe combined immunodeficiency was studied during a 3-month period of bone marrow transplantation and palivizumab infusion. No RSV isolates with palivizumab escape mutations were identified. Donor lymphocytes, including CD8 cells, appeared to markedly reduce the RSV load but increased the pulmonary symptoms. Immunosuppressive therapy ameliorated lung disease but allowed the RSV load to rebound.

Original languageEnglish (US)
JournalClinical Infectious Diseases
Volume39
Issue number2
StatePublished - 2004

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Respiratory Syncytial Virus Infections
Respiratory Syncytial Viruses
Bone Marrow Transplantation
Lung Diseases
Amino Acid Sequence
Glycoproteins
Tissue Donors
T-Lymphocytes
Severe Combined Immunodeficiency
Immunosuppressive Agents
Lymphocytes
Lung
Mutation
Palivizumab
Therapeutics

Cite this

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abstract = "A patient with respiratory syncytial virus (RSV) infection and severe combined immunodeficiency was studied during a 3-month period of bone marrow transplantation and palivizumab infusion. No RSV isolates with palivizumab escape mutations were identified. Donor lymphocytes, including CD8 cells, appeared to markedly reduce the RSV load but increased the pulmonary symptoms. Immunosuppressive therapy ameliorated lung disease but allowed the RSV load to rebound.",
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