Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice

Leslie C. Jones, Kristin A. McCarthy, John L. Beard, Carl L. Keen, Byron Jones

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Copper and zinc are trace nutrients essential for normal brain function, yet an excess of these elements can be toxic. It is important therefore that these metals be closely regulated. We recently conducted a quantitative trait loci (QTL) analysis to identify chromosomal regions in the mouse containing possible regulatory genes. The animals came from 15 strains of the BXD/Ty recombinant inbred (RI) strain panel and the brain regions analyzed were frontal cortex, caudate-putamen, nucleus accumbens and ventral midbrain. Several QTL were identified for copper and/or zinc, most notably on chromosomes 1, 8, 16 and 17. Genetic correlational analysis also revealed associations between these metals and dopamine, cocaine responses, saccharine preference, immune response and seizure susceptibility. Notably, the QTL on chromosome 17 is also associated with seizure susceptibility and contains the histocompatibility H2 complex. This work shows that regulation of zinc and copper is under polygenic influence and is intimately related to CNS function. Future work will reveal genes underlying the QTL and how they interact with other genes and the environment. More importantly, revelation of the genetic underpinnings of copper and zinc brain homeostasis will aid our understanding of neurological diseases that are related to copper and zinc imbalance.

Original languageEnglish (US)
Pages (from-to)81-92
Number of pages12
JournalNutritional Neuroscience
Volume9
Issue number1-2
DOIs
StatePublished - Feb 1 2006

Fingerprint

quantitative genetics
Quantitative Trait Loci
genetic techniques and protocols
Zinc
Copper
copper
zinc
quantitative trait loci
brain
mice
Brain
Chromosomes, Human, Pair 17
seizures
Seizures
Metals
metals
chromosomes
cocaine
Chromosomes, Human, Pair 8
Caudate Nucleus

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice. / Jones, Leslie C.; McCarthy, Kristin A.; Beard, John L.; Keen, Carl L.; Jones, Byron.

In: Nutritional Neuroscience, Vol. 9, No. 1-2, 01.02.2006, p. 81-92.

Research output: Contribution to journalArticle

Jones, Leslie C. ; McCarthy, Kristin A. ; Beard, John L. ; Keen, Carl L. ; Jones, Byron. / Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice. In: Nutritional Neuroscience. 2006 ; Vol. 9, No. 1-2. pp. 81-92.
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