Quantitative histology of the hypertrophied human heart

E. S. Pearlman, Karl Weber, J. S. Janicki

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Myocardial hypertrophy accompanies systemic hypertension and aortic stenosis, i.e., pressure overload. In man cardiac failure only appears after years of pressure overload, during which time cardiac function had been maintained. The structural correlates of cardiac failure have been a subject of much interest for many years. Several hypotheses relating alterations in muscle fiber alignment, capillary density, or collagen content have been offered. The application of morphometric techniques has provided essential quantitative information on the structural components of the normal and diseased heart. These data indicate that muscle fiber alignment remains normal in the pressure overloaded heart despite the presence of hypertrophy or the appearance of clinical failure. On the other hand, capillary density is decreased and collagen content is increased in hypertrophied hearts. Chemical studies on collagen concentration however have yielded inconsistent results. The relative contribution of the microcirculation and collagenous structure of the myocardium on its respective O2 availability, mechanical behavior, and deterioration in pump function will require further investigation.

Original languageEnglish (US)
Pages (from-to)2042-2047
Number of pages6
JournalFederation Proceedings
Volume40
Issue number7
StatePublished - 1981
Externally publishedYes

Fingerprint

Histology
Collagen
Pressure
Hypertrophy
Heart Failure
Muscles
Aortic Valve Stenosis
Microcirculation
Heart Diseases
Myocardium
Hypertension

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Pearlman, E. S., Weber, K., & Janicki, J. S. (1981). Quantitative histology of the hypertrophied human heart. Federation Proceedings, 40(7), 2042-2047.

Quantitative histology of the hypertrophied human heart. / Pearlman, E. S.; Weber, Karl; Janicki, J. S.

In: Federation Proceedings, Vol. 40, No. 7, 1981, p. 2042-2047.

Research output: Contribution to journalArticle

Pearlman, ES, Weber, K & Janicki, JS 1981, 'Quantitative histology of the hypertrophied human heart', Federation Proceedings, vol. 40, no. 7, pp. 2042-2047.
Pearlman, E. S. ; Weber, Karl ; Janicki, J. S. / Quantitative histology of the hypertrophied human heart. In: Federation Proceedings. 1981 ; Vol. 40, No. 7. pp. 2042-2047.
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