Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse

Qing Xiong, Yan Jiao, Karen Hasty, S. Terry Canale, John Stuart, Wesley G. Beamer, Hong Wen Deng, David Baylink, Weikuan Gu

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

This is an in silico analysis of data available from genome-wide scans. Through analysis of QTL, genes and polymorphisms that regulate BMD, we identified 82 BMD QTL, 191 BMD-associated (BMDA) genes, and 83 genes containing known BMD-associated polymorphisms (BMDAP). The catalogue of all BMDA/BMDAP genes and relevant literatures are provided. In total, there are substantially more BMDA/BMDAP genes in regions of the genome where QTL have been identified than in non-QTL regions. Among 191 BMDA genes and 83 BMDAP genes, 133 and 58 are localized in QTL regions, respectively. The difference was still noticeable for the chromosome distribution of these genes between QTL and non-QTL regions. These results have allowed us to generate an integrative profile of QTL, genes, polymorphisms that determine BMD. These data could facilitate more rapid and comprehensive identification of causal genes underlying the determination of BMD in mouse and provide new insights into how BMD is regulated in humans.

Original languageEnglish (US)
Pages (from-to)401-414
Number of pages14
JournalGenomics
Volume93
Issue number5
DOIs
StatePublished - May 1 2009

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Quantitative Trait Loci
Bone Density
Genes
Genome
Computer Simulation
Chromosomes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. / Xiong, Qing; Jiao, Yan; Hasty, Karen; Canale, S. Terry; Stuart, John; Beamer, Wesley G.; Deng, Hong Wen; Baylink, David; Gu, Weikuan.

In: Genomics, Vol. 93, No. 5, 01.05.2009, p. 401-414.

Research output: Contribution to journalReview article

Xiong, Qing ; Jiao, Yan ; Hasty, Karen ; Canale, S. Terry ; Stuart, John ; Beamer, Wesley G. ; Deng, Hong Wen ; Baylink, David ; Gu, Weikuan. / Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. In: Genomics. 2009 ; Vol. 93, No. 5. pp. 401-414.
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AU - Canale, S. Terry

AU - Stuart, John

AU - Beamer, Wesley G.

AU - Deng, Hong Wen

AU - Baylink, David

AU - Gu, Weikuan

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