Quantitative trait loci linked to thalamus and cortex gray matter volumes in BXD recombinant inbred mice

H. Dong, M. V. Martin, J. Colvin, Z. Ali, L. Wang, Lu Lu, Robert Williams, G. D. Rosen, J. G. Csernansky, J. M. Cheverud

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To investigate whether there are separate or shared genetic influences on the development of the thalamus and cerebral cortex, we identified quantitative trait loci (QTLs) for relevant structural volumes in BXD recombinant inbred (RI) strains of mice. In 34 BXD RI strains and two parental strains (C57BL/6J and DBA/2J), we measured the volumes of the entire thalamus and cortex gray matter using point counting and Cavalieri's rule. Heritability was calculated using analysis of variance (ANOVA), and QTL analysis was carried out using WebQTL (http://www.genenetwork.org). The heritability of thalamus volume was 36%, and three suggestive QTLs for thalamus volume were identified on chromosomes 10, 11 and 16. The heritability of cortical gray matter was 43%, and four suggestive QTLs for cortex gray matter volume were identified on chromosomes 2, 8, 16 and 19. The genetic correlation between thalamus and cortex gray matter volumes was 0.64. Also, a single QTL on chromosome 16 (D16Mit100) was identified for thalamus volume, cortex gray matter volume and Morris water maze search-time preference (r=0.71). These results suggest that there are separate and shared genetic influences on the development of the thalamus and cerebral cortex.

Original languageEnglish (US)
Pages (from-to)62-69
Number of pages8
JournalHeredity
Volume99
Issue number1
DOIs
StatePublished - Jul 2 2007

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Quantitative Trait Loci
Thalamus
Chromosomes, Human, Pair 16
Cerebral Cortex
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 11
Inbred Strains Mice
Chromosomes, Human, Pair 2
Gray Matter
Analysis of Variance
Water

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Quantitative trait loci linked to thalamus and cortex gray matter volumes in BXD recombinant inbred mice. / Dong, H.; Martin, M. V.; Colvin, J.; Ali, Z.; Wang, L.; Lu, Lu; Williams, Robert; Rosen, G. D.; Csernansky, J. G.; Cheverud, J. M.

In: Heredity, Vol. 99, No. 1, 02.07.2007, p. 62-69.

Research output: Contribution to journalArticle

Dong, H, Martin, MV, Colvin, J, Ali, Z, Wang, L, Lu, L, Williams, R, Rosen, GD, Csernansky, JG & Cheverud, JM 2007, 'Quantitative trait loci linked to thalamus and cortex gray matter volumes in BXD recombinant inbred mice', Heredity, vol. 99, no. 1, pp. 62-69. https://doi.org/10.1038/sj.hdy.6800965
Dong, H. ; Martin, M. V. ; Colvin, J. ; Ali, Z. ; Wang, L. ; Lu, Lu ; Williams, Robert ; Rosen, G. D. ; Csernansky, J. G. ; Cheverud, J. M. / Quantitative trait loci linked to thalamus and cortex gray matter volumes in BXD recombinant inbred mice. In: Heredity. 2007 ; Vol. 99, No. 1. pp. 62-69.
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