Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ × SJL/J) F2 mice

Godfred L. Masinde, Xinmin Li, Weikuan Gu, Melanie Hamilton-Ulland, Subburaman Mohan, David J. Baylink

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The genetic mechanisms that determine muscle size have not been elucidated, even though it is a key musculoskeletal parameter that reflects muscle strength. In this study, we performed a high-density genome-wide scan using 633 (MRL/MPJ × SJL/J) F2 intercross 7-week-old mice to identify quantitative trait loci (QTL) involved in the determination of muscle size. Significant QTL were identified for muscle size and body length. Muscle size (adjusted by body length) QTL were identified on chromosomes 7, 9, 11, 14 (two QTL) and 17, which together explained 19.2% of phenotypic variance in F 2 mice, while body length QTL were located on chromosome 2 (two QTL), 9, 11 and 17 which accounted for 28.3% of phenotypic variance in F2 mice. Three significant epistatic interactions between different QTL positions from muscle size and body length were identified (P <0.01) on chromosomes 2, 9, 14 and 17, which explained 16.1% of the variance in F2 mice.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalFunctional and Integrative Genomics
Volume2
Issue number3
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

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Quantitative Trait Loci
Muscles
Body Size
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 7
Muscle Strength
Genome

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ × SJL/J) F2 mice. / Masinde, Godfred L.; Li, Xinmin; Gu, Weikuan; Hamilton-Ulland, Melanie; Mohan, Subburaman; Baylink, David J.

In: Functional and Integrative Genomics, Vol. 2, No. 3, 01.12.2002, p. 120-125.

Research output: Contribution to journalArticle

Masinde, Godfred L. ; Li, Xinmin ; Gu, Weikuan ; Hamilton-Ulland, Melanie ; Mohan, Subburaman ; Baylink, David J. / Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ × SJL/J) F2 mice. In: Functional and Integrative Genomics. 2002 ; Vol. 2, No. 3. pp. 120-125.
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