Quinolones

A practical review of clinical uses, dosing considerations, and drug interactions

Shawn M. Borcherding, Robert Stevens, Richard A. Nicholas, Cheryl R. Corley, Timothy Self

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

A review of the literature on quinolones reveals numerous clinically relevant points regarding indications, dosing considerations, and drug interactions. Quinolones are useful in the treatment of several infectious diseases. Unfortunately, indiscriminate use of these valuable antimicrobials has resulted in increased patterns of resistance. It is important to consider carefully the site of infection and the potential pathogens in each patient before dosing. Quinolones have excellent oral absorption, with peak serum concentrations approaching those achieved with intravenous administration. When prescribing quinolones, the dose should be based on estimated creatinine clearance. Quinolones are associated with several clinically significant drug interactions. Some of these agents are well-documented inhibitors of hepatic metabolism of theophylline, caffeine, and warfarin. It has been well documented that divalent and trivalent cations in antacids, sucralfate, and some other products significantly reduce the absorption of quinolones. Avoidance or proper management of these interactions is required to ensure optimal safety and efficacy.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalJournal of Family Practice
Volume42
Issue number1
StatePublished - Jan 1996

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Quinolones
Drug Interactions
Sucralfate
Antacids
Divalent Cations
Warfarin
Theophylline
Caffeine
Intravenous Administration
Communicable Diseases
Creatinine
Safety
Liver
Infection
Serum

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Borcherding, S. M., Stevens, R., Nicholas, R. A., Corley, C. R., & Self, T. (1996). Quinolones: A practical review of clinical uses, dosing considerations, and drug interactions. Journal of Family Practice, 42(1), 69-78.

Quinolones : A practical review of clinical uses, dosing considerations, and drug interactions. / Borcherding, Shawn M.; Stevens, Robert; Nicholas, Richard A.; Corley, Cheryl R.; Self, Timothy.

In: Journal of Family Practice, Vol. 42, No. 1, 01.1996, p. 69-78.

Research output: Contribution to journalReview article

Borcherding, SM, Stevens, R, Nicholas, RA, Corley, CR & Self, T 1996, 'Quinolones: A practical review of clinical uses, dosing considerations, and drug interactions', Journal of Family Practice, vol. 42, no. 1, pp. 69-78.
Borcherding SM, Stevens R, Nicholas RA, Corley CR, Self T. Quinolones: A practical review of clinical uses, dosing considerations, and drug interactions. Journal of Family Practice. 1996 Jan;42(1):69-78.
Borcherding, Shawn M. ; Stevens, Robert ; Nicholas, Richard A. ; Corley, Cheryl R. ; Self, Timothy. / Quinolones : A practical review of clinical uses, dosing considerations, and drug interactions. In: Journal of Family Practice. 1996 ; Vol. 42, No. 1. pp. 69-78.
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