Race, Candida sepsis, and retinopathy of prematurity

Misrak Tadesse, Ramasubbareddy Dhanireddy, Mahdur Mittal, Rosemary D. Higgins

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The objective of this observational cohort study at Georgetown University Hospital from January 1, 1994 through December 31, 1997 was to investigate race, Candida sepsis, and duration of oxygen exposure in infants with retinopathy of prematurity (ROP) with birth weight ≤ 1,000 g. The incidence of ROP was 70.8% (114/161). The incidence of stage III or greater ROP in the Caucasian infants was significantly higher at 46.7% (14/30) than in the African-American infants at 23.8% (20/84) with p < 0.02. In addition, the incidence of threshold disease was higher in Caucasian infants 33.3% (10/30) when compared to African-American infants 9.5% (8/84) with p < 0.002. Using multiple logistic regression, African-American race was found to be an independent protective factor against developing severe ROP [adjusted odds ratio 0.39; 95% confidence interval (UCI) 0.16-0.97]. Extremely-low-birth-weight African-American infants with comparable severity of illness (including birth weight, gestational age, duration of supplemental oxygen exposure, and Candida sepsis) are less likely to develop severe ROP than Caucasian infants.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalBiology of the Neonate
Volume81
Issue number2
DOIs
StatePublished - Feb 28 2002

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Retinopathy of Prematurity
Candida
Sepsis
African Americans
Birth Weight
Incidence
Oxygen
Low Birth Weight Infant
Gestational Age
Observational Studies
Cohort Studies
Logistic Models
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

Cite this

Race, Candida sepsis, and retinopathy of prematurity. / Tadesse, Misrak; Dhanireddy, Ramasubbareddy; Mittal, Mahdur; Higgins, Rosemary D.

In: Biology of the Neonate, Vol. 81, No. 2, 28.02.2002, p. 86-90.

Research output: Contribution to journalArticle

Tadesse, Misrak ; Dhanireddy, Ramasubbareddy ; Mittal, Mahdur ; Higgins, Rosemary D. / Race, Candida sepsis, and retinopathy of prematurity. In: Biology of the Neonate. 2002 ; Vol. 81, No. 2. pp. 86-90.
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