Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents

Pedro A. Velásquez-Mieyer, Patricia A. Cowan, Sylvia Pérez-Faustinelli, Ramfis Nieto-Martínez, Cesar Villegas-Barreto, Elizabeth Tolley, Robert H. Lustig, Bruce S. Alpert

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - Compared with Caucasians, obese African-American adolescents have a higher risk for type 2 diabetes. Subclinical inflammation and reduced glucagon-like peptide 1 (GLP-1) concentration are linked to the pathogenesis of the disease. We determined the relationship between insulin resistance, β-cell activity, and subclinical inflammation with GLP-1 concentrations and whether racial disparities in GLP-1 response were present in 49 obese adolescents (14 ± 3 years; 76% African American; 71% female). RESEARCH DESIGN AND METHODS - Subjects underwent physical examination and an oral glucose tolerance test. We measured levels of high-sensitivity CRP (CRP hs), fibrinogen, glucose, GLP-1 total, GLP-1 active, and insulin. Insulin and glucose area under the curve (AUC), insulinogenic index (ΔI30/ΔG30), and composite insulin sensitivity index (CISI) were computed. Subjects were categorized by race and as inflammation positive (INF+)ifCRP hs or fibrinogen were elevated. RESULTS - No racial differences were seen in mean or relative BMI. Thirty-five percent of subjects had altered fasting or 2-h glucose levels (African American vs. Caucasian, NS), and 75% were INF+ (African American vs. Caucasian, P = 0.046). Glucose and insulin, CISI, and ΔI30/ΔG30 values were similar; African Americans had lower GLP-1 total AUC (P = 0.01), GLP-1 active at 15 min (P = 0.03), and GLP-1 active; AUC (P = 0.06) and higher fibrinogen (P = 0.01) and CRP hs (NS) compared with Caucasians. CONCLUSIONS - African Americans exhibited lower GLP-1 concentrations and increased inflammatory response. Both mechanisms may act synergistically to enhance the predisposition of obese African Americans to type 2 diabetes. Our findings might be relevant to effective deployment of emerging GLP-1-based treatments across ethnicities.

Original languageEnglish (US)
Pages (from-to)770-775
Number of pages6
JournalDiabetes Care
Volume31
Issue number4
DOIs
StatePublished - Apr 1 2008

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Glucagon-Like Peptide 1
Inflammation
African Americans
Fibrinogen
Area Under Curve
Insulin Resistance
Glucose
Insulin
Type 2 Diabetes Mellitus
Glucose Tolerance Test
Physical Examination
Fasting
Research Design

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Velásquez-Mieyer, P. A., Cowan, P. A., Pérez-Faustinelli, S., Nieto-Martínez, R., Villegas-Barreto, C., Tolley, E., ... Alpert, B. S. (2008). Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents. Diabetes Care, 31(4), 770-775. https://doi.org/10.2337/dc07-1525

Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents. / Velásquez-Mieyer, Pedro A.; Cowan, Patricia A.; Pérez-Faustinelli, Sylvia; Nieto-Martínez, Ramfis; Villegas-Barreto, Cesar; Tolley, Elizabeth; Lustig, Robert H.; Alpert, Bruce S.

In: Diabetes Care, Vol. 31, No. 4, 01.04.2008, p. 770-775.

Research output: Contribution to journalArticle

Velásquez-Mieyer, PA, Cowan, PA, Pérez-Faustinelli, S, Nieto-Martínez, R, Villegas-Barreto, C, Tolley, E, Lustig, RH & Alpert, BS 2008, 'Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents', Diabetes Care, vol. 31, no. 4, pp. 770-775. https://doi.org/10.2337/dc07-1525
Velásquez-Mieyer PA, Cowan PA, Pérez-Faustinelli S, Nieto-Martínez R, Villegas-Barreto C, Tolley E et al. Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents. Diabetes Care. 2008 Apr 1;31(4):770-775. https://doi.org/10.2337/dc07-1525
Velásquez-Mieyer, Pedro A. ; Cowan, Patricia A. ; Pérez-Faustinelli, Sylvia ; Nieto-Martínez, Ramfis ; Villegas-Barreto, Cesar ; Tolley, Elizabeth ; Lustig, Robert H. ; Alpert, Bruce S. / Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents. In: Diabetes Care. 2008 ; Vol. 31, No. 4. pp. 770-775.
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abstract = "OBJECTIVE - Compared with Caucasians, obese African-American adolescents have a higher risk for type 2 diabetes. Subclinical inflammation and reduced glucagon-like peptide 1 (GLP-1) concentration are linked to the pathogenesis of the disease. We determined the relationship between insulin resistance, β-cell activity, and subclinical inflammation with GLP-1 concentrations and whether racial disparities in GLP-1 response were present in 49 obese adolescents (14 ± 3 years; 76{\%} African American; 71{\%} female). RESEARCH DESIGN AND METHODS - Subjects underwent physical examination and an oral glucose tolerance test. We measured levels of high-sensitivity CRP (CRP hs), fibrinogen, glucose, GLP-1 total, GLP-1 active, and insulin. Insulin and glucose area under the curve (AUC), insulinogenic index (ΔI30/ΔG30), and composite insulin sensitivity index (CISI) were computed. Subjects were categorized by race and as inflammation positive (INF+)ifCRP hs or fibrinogen were elevated. RESULTS - No racial differences were seen in mean or relative BMI. Thirty-five percent of subjects had altered fasting or 2-h glucose levels (African American vs. Caucasian, NS), and 75{\%} were INF+ (African American vs. Caucasian, P = 0.046). Glucose and insulin, CISI, and ΔI30/ΔG30 values were similar; African Americans had lower GLP-1 total AUC (P = 0.01), GLP-1 active at 15 min (P = 0.03), and GLP-1 active; AUC (P = 0.06) and higher fibrinogen (P = 0.01) and CRP hs (NS) compared with Caucasians. CONCLUSIONS - African Americans exhibited lower GLP-1 concentrations and increased inflammatory response. Both mechanisms may act synergistically to enhance the predisposition of obese African Americans to type 2 diabetes. Our findings might be relevant to effective deployment of emerging GLP-1-based treatments across ethnicities.",
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AU - Nieto-Martínez, Ramfis

AU - Villegas-Barreto, Cesar

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AB - OBJECTIVE - Compared with Caucasians, obese African-American adolescents have a higher risk for type 2 diabetes. Subclinical inflammation and reduced glucagon-like peptide 1 (GLP-1) concentration are linked to the pathogenesis of the disease. We determined the relationship between insulin resistance, β-cell activity, and subclinical inflammation with GLP-1 concentrations and whether racial disparities in GLP-1 response were present in 49 obese adolescents (14 ± 3 years; 76% African American; 71% female). RESEARCH DESIGN AND METHODS - Subjects underwent physical examination and an oral glucose tolerance test. We measured levels of high-sensitivity CRP (CRP hs), fibrinogen, glucose, GLP-1 total, GLP-1 active, and insulin. Insulin and glucose area under the curve (AUC), insulinogenic index (ΔI30/ΔG30), and composite insulin sensitivity index (CISI) were computed. Subjects were categorized by race and as inflammation positive (INF+)ifCRP hs or fibrinogen were elevated. RESULTS - No racial differences were seen in mean or relative BMI. Thirty-five percent of subjects had altered fasting or 2-h glucose levels (African American vs. Caucasian, NS), and 75% were INF+ (African American vs. Caucasian, P = 0.046). Glucose and insulin, CISI, and ΔI30/ΔG30 values were similar; African Americans had lower GLP-1 total AUC (P = 0.01), GLP-1 active at 15 min (P = 0.03), and GLP-1 active; AUC (P = 0.06) and higher fibrinogen (P = 0.01) and CRP hs (NS) compared with Caucasians. CONCLUSIONS - African Americans exhibited lower GLP-1 concentrations and increased inflammatory response. Both mechanisms may act synergistically to enhance the predisposition of obese African Americans to type 2 diabetes. Our findings might be relevant to effective deployment of emerging GLP-1-based treatments across ethnicities.

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