Radiographic patterns of multiple myeloma in the jawbones of patients treated with intravenous bisphosphonates

Karina Morais Faria, Ana Carolina Prado Ribeiro, Thais Bianca Brandão, Wagner Gomes Silva, Marcio Ajudarte Lopes, Juliana Pereira, Marcelo Corrêa Alves, Luiz Alcino Gueiros, Werner Shintaku, Cesar Augusto Migliorati, Alan Roger Santos-Silva

Research output: Contribution to journalArticle

Abstract

Background: The purpose of this study was to evaluate whether intravenous (IV) bisphosphonate (BP) therapy can change the radiographic patterns of multiple myeloma (MM) in the jawbones. Methods: The authors evaluated panoramic radiographs obtained from 188 patients with MM for the presence of solitary osteolytic lesions, multiple osteolytic lesions, diffuse osteoporosis, diffuse sclerosis, lamina dura abnormalities, nonhealing alveolar sockets, and bone sequestration. The authors compared results obtained from patients treated with IV BPs with those obtained from patients who had never been exposed to BPs. Results: Multiple osteolytic lesions (P =.001), diffuse osteoporosis (P =.001), and diffuse sclerosis (P =.0036) occurred more often in the mandible in both groups. Solitary osteolytic lesions occurred less frequently in the BP group (P =.0078). Lamina dura abnormalities (P =.0006) and nonhealing alveolar sockets (P =.0021) were associated with BP treatment. Conclusions: IV BP therapy changes the radiographic patterns of MM in the jawbones. Practical Implications: The effect of BPs in the maxillofacial area is a matter of concern for health practitioners because this type of medication causes several alterations of the jawbones in patients with cancer.

Original languageEnglish (US)
Pages (from-to)382-391
Number of pages10
JournalJournal of the American Dental Association
Volume149
Issue number5
DOIs
StatePublished - May 1 2018

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Diphosphonates
Multiple Myeloma
Sclerosis
Osteoporosis
Mandible
Therapeutics
Bone and Bones
Health
Neoplasms

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Faria, K. M., Ribeiro, A. C. P., Brandão, T. B., Silva, W. G., Lopes, M. A., Pereira, J., ... Santos-Silva, A. R. (2018). Radiographic patterns of multiple myeloma in the jawbones of patients treated with intravenous bisphosphonates. Journal of the American Dental Association, 149(5), 382-391. https://doi.org/10.1016/j.adaj.2017.12.028

Radiographic patterns of multiple myeloma in the jawbones of patients treated with intravenous bisphosphonates. / Faria, Karina Morais; Ribeiro, Ana Carolina Prado; Brandão, Thais Bianca; Silva, Wagner Gomes; Lopes, Marcio Ajudarte; Pereira, Juliana; Alves, Marcelo Corrêa; Gueiros, Luiz Alcino; Shintaku, Werner; Migliorati, Cesar Augusto; Santos-Silva, Alan Roger.

In: Journal of the American Dental Association, Vol. 149, No. 5, 01.05.2018, p. 382-391.

Research output: Contribution to journalArticle

Faria, KM, Ribeiro, ACP, Brandão, TB, Silva, WG, Lopes, MA, Pereira, J, Alves, MC, Gueiros, LA, Shintaku, W, Migliorati, CA & Santos-Silva, AR 2018, 'Radiographic patterns of multiple myeloma in the jawbones of patients treated with intravenous bisphosphonates', Journal of the American Dental Association, vol. 149, no. 5, pp. 382-391. https://doi.org/10.1016/j.adaj.2017.12.028
Faria, Karina Morais ; Ribeiro, Ana Carolina Prado ; Brandão, Thais Bianca ; Silva, Wagner Gomes ; Lopes, Marcio Ajudarte ; Pereira, Juliana ; Alves, Marcelo Corrêa ; Gueiros, Luiz Alcino ; Shintaku, Werner ; Migliorati, Cesar Augusto ; Santos-Silva, Alan Roger. / Radiographic patterns of multiple myeloma in the jawbones of patients treated with intravenous bisphosphonates. In: Journal of the American Dental Association. 2018 ; Vol. 149, No. 5. pp. 382-391.
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AU - Ribeiro, Ana Carolina Prado

AU - Brandão, Thais Bianca

AU - Silva, Wagner Gomes

AU - Lopes, Marcio Ajudarte

AU - Pereira, Juliana

AU - Alves, Marcelo Corrêa

AU - Gueiros, Luiz Alcino

AU - Shintaku, Werner

AU - Migliorati, Cesar Augusto

AU - Santos-Silva, Alan Roger

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AB - Background: The purpose of this study was to evaluate whether intravenous (IV) bisphosphonate (BP) therapy can change the radiographic patterns of multiple myeloma (MM) in the jawbones. Methods: The authors evaluated panoramic radiographs obtained from 188 patients with MM for the presence of solitary osteolytic lesions, multiple osteolytic lesions, diffuse osteoporosis, diffuse sclerosis, lamina dura abnormalities, nonhealing alveolar sockets, and bone sequestration. The authors compared results obtained from patients treated with IV BPs with those obtained from patients who had never been exposed to BPs. Results: Multiple osteolytic lesions (P =.001), diffuse osteoporosis (P =.001), and diffuse sclerosis (P =.0036) occurred more often in the mandible in both groups. Solitary osteolytic lesions occurred less frequently in the BP group (P =.0078). Lamina dura abnormalities (P =.0006) and nonhealing alveolar sockets (P =.0021) were associated with BP treatment. Conclusions: IV BP therapy changes the radiographic patterns of MM in the jawbones. Practical Implications: The effect of BPs in the maxillofacial area is a matter of concern for health practitioners because this type of medication causes several alterations of the jawbones in patients with cancer.

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