Radioguided parathyroidectomy effective in pediatric patients

Jocelyn F. Burke, Kaitlin Jacobson, Ankush Gosain, Rebecca S. Sippel, Herbert Chen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Radioguided parathyroidectomy (RGP) has been shown to be effective in adult patients with hyperparathyroidism (HPT), but the utility of RGP in pediatric patients has not been systematically examined. It is not known if adult criteria for radioactive counts can accurately detect hyperfunctioning parathyroid glands in pediatric patients. The purpose of our study was to determine the utility of RGP in children with primary HPT. Materials and methods: A retrospective review of our prospectively maintained singleinstitution database for patients who underwent a RGP for primary HPT identified 1694 adult and 19 pediatric patients aged 19 y or younger. From the adult population, we selected a control group matched three to one for gland weight and gender and compared pre- and postoperative laboratory values, surgical findings, pathology, and radioguidance values between the control and the pediatric groups. Results: Excised glands from pediatric patients were smaller than those in the total adult population (437 ± 60 mg versus 718 ± 31 mg, P = 0.0004). When controlled for gland weight, ex vivo counts as a percentage of background were lower in the pediatric group (51% ± 5% versus 91% ± 11%, P = 0.04). However, ex vivo radionuclide counts >20% of the background were found in 100% of pediatric patients and 95% of the adult-matched control group. Conclusions: All pediatric patients met the adult detection criteria for parathyroid tissue removal when a RGP was performed, and 100% cure was achieved. We conclude that RGP is a useful treatment option for pediatric patients with primary HPT.

Original languageEnglish (US)
Pages (from-to)312-317
Number of pages6
JournalJournal of Surgical Research
Volume184
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

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Parathyroidectomy
Pediatrics
Primary Hyperparathyroidism
Control Groups
Weights and Measures
Surgical Pathology
Parathyroid Glands
Hyperparathyroidism
Radioisotopes
Population
Research Design
Databases

All Science Journal Classification (ASJC) codes

  • Surgery

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Radioguided parathyroidectomy effective in pediatric patients. / Burke, Jocelyn F.; Jacobson, Kaitlin; Gosain, Ankush; Sippel, Rebecca S.; Chen, Herbert.

In: Journal of Surgical Research, Vol. 184, No. 1, 01.01.2013, p. 312-317.

Research output: Contribution to journalArticle

Burke, Jocelyn F. ; Jacobson, Kaitlin ; Gosain, Ankush ; Sippel, Rebecca S. ; Chen, Herbert. / Radioguided parathyroidectomy effective in pediatric patients. In: Journal of Surgical Research. 2013 ; Vol. 184, No. 1. pp. 312-317.
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