Radioiodinations of organic molecules on silica gel surfaces

Thomas E. Boothe, Ronald D. Finn, Manhar M. Vora, Ali Emran, Paresh J. Kothari, George Kabalka

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To investigate radioiodinations on chromatographic surfaces, 131I has been allowed to react with various organic compounds on silica gel chromatography plates. Antipyrine, which reacts with 131I to give 4‐[131I]iodoantipyrine, was used as a model compound. The yield varied as a function of the initial solvent used; hydrogen ion concentration; contact time on the surface; and temperature. These results were extended to other reactive compounds such as substituted 3H‐pyrazol‐3‐ones; substituted phenols, including L‐tyrosine; substituted anilines; 5‐iodouracil; some secondary alkyliodides and alkylbromides; alkylboranes; and aryl‐and vinylboronic acids.

Original languageEnglish (US)
Pages (from-to)1109-1122
Number of pages14
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume22
Issue number11
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Aniline Compounds
Antipyrine
Phenols
Silica Gel
Gel Chromatography
pH
Molecules
Temperature
Acids
Chromatography
Organic compounds
iodoantipyrine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Cite this

Radioiodinations of organic molecules on silica gel surfaces. / Boothe, Thomas E.; Finn, Ronald D.; Vora, Manhar M.; Emran, Ali; Kothari, Paresh J.; Kabalka, George.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 22, No. 11, 01.01.1985, p. 1109-1122.

Research output: Contribution to journalArticle

Boothe, Thomas E. ; Finn, Ronald D. ; Vora, Manhar M. ; Emran, Ali ; Kothari, Paresh J. ; Kabalka, George. / Radioiodinations of organic molecules on silica gel surfaces. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1985 ; Vol. 22, No. 11. pp. 1109-1122.
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