RAGE

A new target for the prevention and treatment of the vascular and inflammatory complications of diabetes

Ann Marie Schmidt, David Stern

Research output: Contribution to journalReview article

136 Citations (Scopus)

Abstract

Although the underlying causes of hyperglycemia are multiple, a common thread associated with high levels of blood sugar is the development of a range of vascular and inflammatory complications that might seriously limit the quality and duration of life in affected individuals. Despite multiple aggressive efforts to prevent complications, diabetes remains the leading disease consuming healthcare dollars in the USA. This review focuses on the role of advanced glycation endproducts (AGEs) and their interaction with their signal-transduction AGE receptor (RAGE), in vascular and inflammatory cell perturbation and the chronic activation that underlies diabetes. Our studies provide mechanistic insights into complications within the macrovasculature and those ensuing from an exaggerated host response to invading bacteria, and suggest that blockade of RAGE might provide a potent and safe strategy for the prevention of complications that typify long, term diabetes.

Original languageEnglish (US)
Pages (from-to)368-375
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume11
Issue number9
DOIs
StatePublished - Oct 28 2000

Fingerprint

Diabetes Complications
Blood Vessels
Hyperglycemia
Blood Glucose
Signal Transduction
Quality of Life
Bacteria
Delivery of Health Care
Advanced Glycosylation End Product-Specific Receptor

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

RAGE : A new target for the prevention and treatment of the vascular and inflammatory complications of diabetes. / Schmidt, Ann Marie; Stern, David.

In: Trends in Endocrinology and Metabolism, Vol. 11, No. 9, 28.10.2000, p. 368-375.

Research output: Contribution to journalReview article

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