RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Shi Du Yan, Xi Chen, Jin Fu, Ming Chen, Huaijie Zhu, Alex Roher, Timothy Slattery, Lei Zhao, Mariko Nagashima, John Morser, Antonio Migheli, Peter Nawroth, David Stern, Ann Marie Schmidt

Research output: Contribution to journalArticle

1608 Citations (Scopus)

Abstract

Amyloid-beta peptide is central to the pathology of Alzheimer's disease, because it is neurotoxic-directly by inducing oxidant stress, and indirectly by activating microglia. A specific cell-surface acceptor site that could focus its effects on target cells has been postulated but not identified. Here we present evidence that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia. Increased expression of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death.

Original languageEnglish (US)
Pages (from-to)685-691
Number of pages7
JournalNature
Volume382
Issue number6593
DOIs
StatePublished - Aug 22 1996

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Microglia
Amyloid
Alzheimer Disease
Peptides
Amyloid beta-Peptides
Oxidants
Pathology
Neurons
Brain
Advanced Glycosylation End Product-Specific Receptor

All Science Journal Classification (ASJC) codes

  • General

Cite this

Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., ... Schmidt, A. M. (1996). RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature, 382(6593), 685-691. https://doi.org/10.1038/382685a0

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. / Yan, Shi Du; Chen, Xi; Fu, Jin; Chen, Ming; Zhu, Huaijie; Roher, Alex; Slattery, Timothy; Zhao, Lei; Nagashima, Mariko; Morser, John; Migheli, Antonio; Nawroth, Peter; Stern, David; Schmidt, Ann Marie.

In: Nature, Vol. 382, No. 6593, 22.08.1996, p. 685-691.

Research output: Contribution to journalArticle

Yan, SD, Chen, X, Fu, J, Chen, M, Zhu, H, Roher, A, Slattery, T, Zhao, L, Nagashima, M, Morser, J, Migheli, A, Nawroth, P, Stern, D & Schmidt, AM 1996, 'RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease', Nature, vol. 382, no. 6593, pp. 685-691. https://doi.org/10.1038/382685a0
Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A et al. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature. 1996 Aug 22;382(6593):685-691. https://doi.org/10.1038/382685a0
Yan, Shi Du ; Chen, Xi ; Fu, Jin ; Chen, Ming ; Zhu, Huaijie ; Roher, Alex ; Slattery, Timothy ; Zhao, Lei ; Nagashima, Mariko ; Morser, John ; Migheli, Antonio ; Nawroth, Peter ; Stern, David ; Schmidt, Ann Marie. / RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. In: Nature. 1996 ; Vol. 382, No. 6593. pp. 685-691.
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