RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease

L. G. Bucciarelli, T. Wendt, L. Rong, E. Lalla, M. A. Hofmann, M. T. Goova, A. Taguchi, S. F. Yan, S. D. Yan, D. M. Stern, A. M. Schmidt

Research output: Contribution to journalReview article

236 Citations (Scopus)

Abstract

Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes ofligands, including advance glycation end-products, amyloid β peptide and the family of β sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.

Original languageEnglish (US)
Pages (from-to)1117-1128
Number of pages12
JournalCellular and Molecular Life Sciences
Volume59
Issue number7
DOIs
StatePublished - Jul 1 2002

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Immunoglobulins
Homeostasis
Chronic Disease
Ligands
Leukocyte L1 Antigen Complex
HMGB1 Protein
Amyloid
Neurodegenerative Diseases
Inflammation
Peptides
Advanced Glycosylation End Product-Specific Receptor
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., ... Schmidt, A. M. (2002). RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease. Cellular and Molecular Life Sciences, 59(7), 1117-1128. https://doi.org/10.1007/s00018-002-8491-x

RAGE is a multiligand receptor of the immunoglobulin superfamily : Implications for homeostasis and chronic disease. / Bucciarelli, L. G.; Wendt, T.; Rong, L.; Lalla, E.; Hofmann, M. A.; Goova, M. T.; Taguchi, A.; Yan, S. F.; Yan, S. D.; Stern, D. M.; Schmidt, A. M.

In: Cellular and Molecular Life Sciences, Vol. 59, No. 7, 01.07.2002, p. 1117-1128.

Research output: Contribution to journalReview article

Bucciarelli, LG, Wendt, T, Rong, L, Lalla, E, Hofmann, MA, Goova, MT, Taguchi, A, Yan, SF, Yan, SD, Stern, DM & Schmidt, AM 2002, 'RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease', Cellular and Molecular Life Sciences, vol. 59, no. 7, pp. 1117-1128. https://doi.org/10.1007/s00018-002-8491-x
Bucciarelli, L. G. ; Wendt, T. ; Rong, L. ; Lalla, E. ; Hofmann, M. A. ; Goova, M. T. ; Taguchi, A. ; Yan, S. F. ; Yan, S. D. ; Stern, D. M. ; Schmidt, A. M. / RAGE is a multiligand receptor of the immunoglobulin superfamily : Implications for homeostasis and chronic disease. In: Cellular and Molecular Life Sciences. 2002 ; Vol. 59, No. 7. pp. 1117-1128.
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