Rapid and mild syntheses of radioiodine-labeled radiopharmaceuticals

George Kabalka, E. E. Gooch, K. A.R. Sastry

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Radioiodine-labeled pharmaceuticals have been used extensively in diagnostic nuclear medicine. We have developed a rapid and mild method for incorporating radioiodine into functionally substituted molecules. The new process involves the reaction of the radioiodide ion with organoboranes in the presence of gentle oxidizing reagents. The radioiodide is utilized nearly quantitatively in a matter of seconds. The radiochemical yields are excellent, and parallel those obtained when iodine monochloride is reacted with organoboranes.

Original languageEnglish (US)
Pages (from-to)908-912
Number of pages5
JournalJournal of Nuclear Medicine
Volume22
Issue number10
StatePublished - Jan 1 1981
Externally publishedYes

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Radiopharmaceuticals
Nuclear Medicine
Ions
Pharmaceutical Preparations
iodine monochloride

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Rapid and mild syntheses of radioiodine-labeled radiopharmaceuticals. / Kabalka, George; Gooch, E. E.; Sastry, K. A.R.

In: Journal of Nuclear Medicine, Vol. 22, No. 10, 01.01.1981, p. 908-912.

Research output: Contribution to journalArticle

Kabalka, George ; Gooch, E. E. ; Sastry, K. A.R. / Rapid and mild syntheses of radioiodine-labeled radiopharmaceuticals. In: Journal of Nuclear Medicine. 1981 ; Vol. 22, No. 10. pp. 908-912.
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