Rapid and sensitive detection of bisphenol a from serum matrix

Xiaogang Lin, Cheng Cheng, Paul Terry, Jiangang Chen, Haochen Cui, Jayne Wu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Bisphenol A (BPA) is an endocrine disrupting compound that may have adverse developmental, reproductive, neurological, and immune system effects. Low-level exposure to BPA is ubiquitous in human populations due to its widespread use in consumer products. Therefore, highly sensitive methods are needed to quantify BPA in various matrices including water, serum, and food products. In this study, we developed a simple, rapid, highly sensitive and specific sensor based on an aptamer probe and AC electrokinetics capacitive sensing method that successfully detected BPA at femto molar (fM) levels, which is an improvement over prior work by a factor of 10. We were able to detect BPA spiked in human serum as well as in maternal and cord blood within 30 s. The sensor is responsive to BPA down to femto molar levels, but not to structurally similar compounds including bisphenol F (BPF) or bisphenol S (BPS) even at much higher concentration. Further development of this platform may prove useful in monitoring exposure to BPA and other small molecules in various matrices.

Original languageEnglish (US)
Pages (from-to)104-109
Number of pages6
JournalBiosensors and Bioelectronics
Volume91
DOIs
StatePublished - May 15 2017
Externally publishedYes

Fingerprint

Consumer products
Immune system
Sensors
Serum
Blood
Molecules
Monitoring
Water
bisphenol A
Fetal Blood
Immune System
Mothers
Food
Population

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

Cite this

Rapid and sensitive detection of bisphenol a from serum matrix. / Lin, Xiaogang; Cheng, Cheng; Terry, Paul; Chen, Jiangang; Cui, Haochen; Wu, Jayne.

In: Biosensors and Bioelectronics, Vol. 91, 15.05.2017, p. 104-109.

Research output: Contribution to journalArticle

Lin, Xiaogang ; Cheng, Cheng ; Terry, Paul ; Chen, Jiangang ; Cui, Haochen ; Wu, Jayne. / Rapid and sensitive detection of bisphenol a from serum matrix. In: Biosensors and Bioelectronics. 2017 ; Vol. 91. pp. 104-109.
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