Rapid infusion of a loading dose of intravenous levetiracetam with minimal dilution

a safety study.

James Wheless, Dave Clarke, Collin A. Hovinga, Michelle Ellis, Misha Durmeier, Amy McGregor, Fred Perkins

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Intravenous antiepileptic drugs are required in patients needing urgent treatment or unable to take oral medication. The safety of intravenous levetiracetam has been established in prospective studies of adult epilepsy and healthy participants. The authors performed a prospective, single-center study to evaluate the safety of a rapid loading dose of intravenous levetiracetam. Patients were divided into 3 equal dosing groups (N = 15 each): 20, 40, and 60 mg/kg (corresponding to maximum doses of 1, 2, and 3 g). Electrocardiogram and safety assessment were performed during the infusion. Ages were 4 to 32 years. Postinfusion serum levetiracetam concentrations were 14 to 189 microg/mL. There were no significant changes in blood pressure, no local infusion site reactions, and no electrocardiogram abnormalities. The authors concluded that high serum levels of parenteral levetiracetam can be achieved rapidly and safely, in a small infusion volume. This finding has important implications for the treatment of status epilepticus.

Original languageEnglish (US)
Pages (from-to)946-951
Number of pages6
JournalJournal of Child Neurology
Volume24
Issue number8
DOIs
StatePublished - Jan 1 2009

Fingerprint

etiracetam
Safety
Electrocardiography
Status Epilepticus
Serum
Anticonvulsants
Epilepsy
Healthy Volunteers
Prospective Studies
Blood Pressure
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Rapid infusion of a loading dose of intravenous levetiracetam with minimal dilution : a safety study. / Wheless, James; Clarke, Dave; Hovinga, Collin A.; Ellis, Michelle; Durmeier, Misha; McGregor, Amy; Perkins, Fred.

In: Journal of Child Neurology, Vol. 24, No. 8, 01.01.2009, p. 946-951.

Research output: Contribution to journalArticle

Wheless, James ; Clarke, Dave ; Hovinga, Collin A. ; Ellis, Michelle ; Durmeier, Misha ; McGregor, Amy ; Perkins, Fred. / Rapid infusion of a loading dose of intravenous levetiracetam with minimal dilution : a safety study. In: Journal of Child Neurology. 2009 ; Vol. 24, No. 8. pp. 946-951.
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