Re-evaluating the role of vitamin D in the periodontium

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The importance of vitamin D in maintaining skeletal health via the regulation of calcium has long been recognized as a critical function of this secosteroid. An abundance of literature shows an association between oral bone mineral density and some measure of systemic osteoporosis and suggests that osteoporosis/low bone mass may be a risk factor for periodontal disease. Recently, nonskeletal functions of vitamin D have gained notoriety for several reasons. Many cells that are not associated with calcium homeostasis have been demonstrated to possess membrane receptors for vitamin D. These include activated T and B lymphocytes, and skin, placenta, pancreas, prostate and colon cancer cells. In addition, vitamin D "insufficiency" is a worldwide epidemic and epidemiologic evidence has linked this condition to multiple chronic health problems, including cardiovascular and autoimmune diseases, hypertension and a variety of cancers. Interestingly, there is mounting evidence connecting diminished serum levels of vitamin D with increased gingival inflammation and supporting the concept of "continual vitamin D sufficiency" in maintaining periodontal health. The ability of vitamin D to regulate both the innate and the adaptive components of the host response may play an important role in this process. This review will examine the skeletal and nonskeletal functions of vitamin D, and explore its potential role in protecting the periodontium as well as in regulating periodontal wound healing.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalJournal of Periodontal Research
Volume49
Issue number5
DOIs
StatePublished - Jan 1 2014

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Periodontium
Vitamin D
Osteoporosis
Secosteroids
Calcium
Calcitriol Receptors
Health
Periodontal Diseases
Skin Neoplasms
Pancreatic Neoplasms
Bone Density
Wound Healing
Colonic Neoplasms
Placenta
Autoimmune Diseases
Prostatic Neoplasms
Homeostasis
B-Lymphocytes
Cardiovascular Diseases
Hypertension

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

Re-evaluating the role of vitamin D in the periodontium. / Stein, Sidney; Livada, R.; Tipton, David.

In: Journal of Periodontal Research, Vol. 49, No. 5, 01.01.2014, p. 545-553.

Research output: Contribution to journalReview article

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