Reactivity of monoclonal antibodies 17.13 and 63.12 with 141 oral mucosal lesions

Cesar Migliorati, R. Ranken, M. J. Kaplan, S. Silverman

Research output: Contribution to journalArticle

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Abstract

We studied the reactivity of monoclonal antibodies (MAbs) 17.13 and 63.12 with normal and diseased human oral mucosa by means of the immunoperoxidase technique. The specimens included: 22 normal oral tissues, 20 benign tumors, 17 lichen planus, 23 focal keratosis and epithelial hyperplasias, 18 proliferative verrucous leukoplakias, 20 dysplasias, and 21 squamous cell carcinomas. In most cases of normal mucosa and benign lesions, MAb 17.13 stained basal epithelial cells only, whereas MAb 63.12 stained all cell layers above the basal cells. In the premalignant and malignant lesions MAb 17.13 stained above the basal cells and MAb 63.12 either stained areas not stained by MAb 17.13 or the staining was absent. Based on the different staining patterns observed, there appears to be a potential value of these new reagents in diagnostic histopathology regarding specimens with equivocal cellular morphology.

Original languageEnglish (US)
Pages (from-to)412-417
Number of pages6
JournalJournal of Oral Pathology & Medicine
Volume21
Issue number9
DOIs
StatePublished - Jan 1 1992

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Monoclonal Antibodies
Focal Epithelial Hyperplasia
Staining and Labeling
Leukoplakia
Keratosis
Lichen Planus
Mouth Mucosa
Immunoenzyme Techniques
Squamous Cell Carcinoma
Mucous Membrane
Epithelial Cells
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Cite this

Reactivity of monoclonal antibodies 17.13 and 63.12 with 141 oral mucosal lesions. / Migliorati, Cesar; Ranken, R.; Kaplan, M. J.; Silverman, S.

In: Journal of Oral Pathology & Medicine, Vol. 21, No. 9, 01.01.1992, p. 412-417.

Research output: Contribution to journalArticle

Migliorati, Cesar ; Ranken, R. ; Kaplan, M. J. ; Silverman, S. / Reactivity of monoclonal antibodies 17.13 and 63.12 with 141 oral mucosal lesions. In: Journal of Oral Pathology & Medicine. 1992 ; Vol. 21, No. 9. pp. 412-417.
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