'Real-world' comparison of first-line direct aspiration and stent retriever mechanical thrombectomy for the treatment of acute ischemic stroke in the anterior circulation

A multicenter international retrospective study

Michael Martini, J. Mocco, Aquilla Turk, Adnan H. Siddiqui, David Fiorella, Ricardo A. Hanel, Keith Woodward, Ansaar Rai, Don Frei, Josser E. Delgado Almandoz, Michael E. Kelly, Lissa Peeling, Adam Arthur, Blaise Baxter, Joey English, Italo Linfante, Reade De Leacy

Research output: Contribution to journalArticle

Abstract

Background Thrombectomy for anterior large vessel occlusion less than 24 hours since last known well is now standard of care. Certain aspects of clinical trials may limit generalizability to 'real-world' practice. Objective To compare revascularization rates and outcomes for direct aspiration (ADAPT) and stent retriever thrombectomy following anterior acute ischemic stroke (AIS) in a real-life setting. Methods Data from the most recent 20 consecutive patients with AIS treated with mechanical thrombectomy between 2015 and 2016 were collected from 15 high-volume stroke centers across North America for a total of 300 cases. Patients with proximal anterior large vessel occlusions were dichotomized by primary treatment technique. Ordinal logistic regression assessed the effects of clinical variables on patient disability using 90-day modified Rankin Scale (mRS) scores. Results Adequate revascularization (Thrombolysis in Cerebral Infarction ≥2b) was ultimately achieved in 91.2% of first-line direct aspiration (ADAPT) cases with an average of 1.9±1.9 passes and in 87.5% of stent retriever cases with an average of 1.7±1.0 passes. Time from groin puncture to revascularization was shorter for ADAPT cases. The mean 90-day mRS score for both groups was 3.0±2.4. Number of passes using primary technique, and postintervention intracranial hemorrhage, were significant predictors of 90-day mRS scores after ADAPT, while age and preprocedure mRS score were predictive of outcomes following first-line stent retriever. Conclusions Our data show similar adequate revascularization rates and 90-day functional outcomes for first-line direct aspiration and stent retrievers for anterior large vessel occlusion in a real-world setting. These results support the findings of other prospective trials evaluating the two techniques.

Original languageEnglish (US)
Pages (from-to)957-963
Number of pages7
JournalJournal of neurointerventional surgery
Volume11
Issue number10
DOIs
StatePublished - Oct 1 2019

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Thrombectomy
Stents
Retrospective Studies
Stroke
Groin
Intracranial Hemorrhages
Cerebral Infarction
Therapeutics
Standard of Care
North America
Punctures
Stroke Volume
Logistic Models
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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'Real-world' comparison of first-line direct aspiration and stent retriever mechanical thrombectomy for the treatment of acute ischemic stroke in the anterior circulation : A multicenter international retrospective study. / Martini, Michael; Mocco, J.; Turk, Aquilla; Siddiqui, Adnan H.; Fiorella, David; Hanel, Ricardo A.; Woodward, Keith; Rai, Ansaar; Frei, Don; Delgado Almandoz, Josser E.; Kelly, Michael E.; Peeling, Lissa; Arthur, Adam; Baxter, Blaise; English, Joey; Linfante, Italo; De Leacy, Reade.

In: Journal of neurointerventional surgery, Vol. 11, No. 10, 01.10.2019, p. 957-963.

Research output: Contribution to journalArticle

Martini, M, Mocco, J, Turk, A, Siddiqui, AH, Fiorella, D, Hanel, RA, Woodward, K, Rai, A, Frei, D, Delgado Almandoz, JE, Kelly, ME, Peeling, L, Arthur, A, Baxter, B, English, J, Linfante, I & De Leacy, R 2019, ''Real-world' comparison of first-line direct aspiration and stent retriever mechanical thrombectomy for the treatment of acute ischemic stroke in the anterior circulation: A multicenter international retrospective study', Journal of neurointerventional surgery, vol. 11, no. 10, pp. 957-963. https://doi.org/10.1136/neurintsurg-2018-014624
Martini, Michael ; Mocco, J. ; Turk, Aquilla ; Siddiqui, Adnan H. ; Fiorella, David ; Hanel, Ricardo A. ; Woodward, Keith ; Rai, Ansaar ; Frei, Don ; Delgado Almandoz, Josser E. ; Kelly, Michael E. ; Peeling, Lissa ; Arthur, Adam ; Baxter, Blaise ; English, Joey ; Linfante, Italo ; De Leacy, Reade. / 'Real-world' comparison of first-line direct aspiration and stent retriever mechanical thrombectomy for the treatment of acute ischemic stroke in the anterior circulation : A multicenter international retrospective study. In: Journal of neurointerventional surgery. 2019 ; Vol. 11, No. 10. pp. 957-963.
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abstract = "Background Thrombectomy for anterior large vessel occlusion less than 24 hours since last known well is now standard of care. Certain aspects of clinical trials may limit generalizability to 'real-world' practice. Objective To compare revascularization rates and outcomes for direct aspiration (ADAPT) and stent retriever thrombectomy following anterior acute ischemic stroke (AIS) in a real-life setting. Methods Data from the most recent 20 consecutive patients with AIS treated with mechanical thrombectomy between 2015 and 2016 were collected from 15 high-volume stroke centers across North America for a total of 300 cases. Patients with proximal anterior large vessel occlusions were dichotomized by primary treatment technique. Ordinal logistic regression assessed the effects of clinical variables on patient disability using 90-day modified Rankin Scale (mRS) scores. Results Adequate revascularization (Thrombolysis in Cerebral Infarction ≥2b) was ultimately achieved in 91.2{\%} of first-line direct aspiration (ADAPT) cases with an average of 1.9±1.9 passes and in 87.5{\%} of stent retriever cases with an average of 1.7±1.0 passes. Time from groin puncture to revascularization was shorter for ADAPT cases. The mean 90-day mRS score for both groups was 3.0±2.4. Number of passes using primary technique, and postintervention intracranial hemorrhage, were significant predictors of 90-day mRS scores after ADAPT, while age and preprocedure mRS score were predictive of outcomes following first-line stent retriever. Conclusions Our data show similar adequate revascularization rates and 90-day functional outcomes for first-line direct aspiration and stent retrievers for anterior large vessel occlusion in a real-world setting. These results support the findings of other prospective trials evaluating the two techniques.",
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T1 - 'Real-world' comparison of first-line direct aspiration and stent retriever mechanical thrombectomy for the treatment of acute ischemic stroke in the anterior circulation

T2 - A multicenter international retrospective study

AU - Martini, Michael

AU - Mocco, J.

AU - Turk, Aquilla

AU - Siddiqui, Adnan H.

AU - Fiorella, David

AU - Hanel, Ricardo A.

AU - Woodward, Keith

AU - Rai, Ansaar

AU - Frei, Don

AU - Delgado Almandoz, Josser E.

AU - Kelly, Michael E.

AU - Peeling, Lissa

AU - Arthur, Adam

AU - Baxter, Blaise

AU - English, Joey

AU - Linfante, Italo

AU - De Leacy, Reade

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background Thrombectomy for anterior large vessel occlusion less than 24 hours since last known well is now standard of care. Certain aspects of clinical trials may limit generalizability to 'real-world' practice. Objective To compare revascularization rates and outcomes for direct aspiration (ADAPT) and stent retriever thrombectomy following anterior acute ischemic stroke (AIS) in a real-life setting. Methods Data from the most recent 20 consecutive patients with AIS treated with mechanical thrombectomy between 2015 and 2016 were collected from 15 high-volume stroke centers across North America for a total of 300 cases. Patients with proximal anterior large vessel occlusions were dichotomized by primary treatment technique. Ordinal logistic regression assessed the effects of clinical variables on patient disability using 90-day modified Rankin Scale (mRS) scores. Results Adequate revascularization (Thrombolysis in Cerebral Infarction ≥2b) was ultimately achieved in 91.2% of first-line direct aspiration (ADAPT) cases with an average of 1.9±1.9 passes and in 87.5% of stent retriever cases with an average of 1.7±1.0 passes. Time from groin puncture to revascularization was shorter for ADAPT cases. The mean 90-day mRS score for both groups was 3.0±2.4. Number of passes using primary technique, and postintervention intracranial hemorrhage, were significant predictors of 90-day mRS scores after ADAPT, while age and preprocedure mRS score were predictive of outcomes following first-line stent retriever. Conclusions Our data show similar adequate revascularization rates and 90-day functional outcomes for first-line direct aspiration and stent retrievers for anterior large vessel occlusion in a real-world setting. These results support the findings of other prospective trials evaluating the two techniques.

AB - Background Thrombectomy for anterior large vessel occlusion less than 24 hours since last known well is now standard of care. Certain aspects of clinical trials may limit generalizability to 'real-world' practice. Objective To compare revascularization rates and outcomes for direct aspiration (ADAPT) and stent retriever thrombectomy following anterior acute ischemic stroke (AIS) in a real-life setting. Methods Data from the most recent 20 consecutive patients with AIS treated with mechanical thrombectomy between 2015 and 2016 were collected from 15 high-volume stroke centers across North America for a total of 300 cases. Patients with proximal anterior large vessel occlusions were dichotomized by primary treatment technique. Ordinal logistic regression assessed the effects of clinical variables on patient disability using 90-day modified Rankin Scale (mRS) scores. Results Adequate revascularization (Thrombolysis in Cerebral Infarction ≥2b) was ultimately achieved in 91.2% of first-line direct aspiration (ADAPT) cases with an average of 1.9±1.9 passes and in 87.5% of stent retriever cases with an average of 1.7±1.0 passes. Time from groin puncture to revascularization was shorter for ADAPT cases. The mean 90-day mRS score for both groups was 3.0±2.4. Number of passes using primary technique, and postintervention intracranial hemorrhage, were significant predictors of 90-day mRS scores after ADAPT, while age and preprocedure mRS score were predictive of outcomes following first-line stent retriever. Conclusions Our data show similar adequate revascularization rates and 90-day functional outcomes for first-line direct aspiration and stent retrievers for anterior large vessel occlusion in a real-world setting. These results support the findings of other prospective trials evaluating the two techniques.

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DO - 10.1136/neurintsurg-2018-014624

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