Recent and emerging anti-diabetes targets

Michael L. Mohler, Yali He, Zhongzhi Wu, Jin Hwang Dong, Duane Miller

Research output: Contribution to journalReview article

69 Citations (Scopus)

Abstract

Diabetes is a disease that affects over 150 million people worldwide for which there are multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, diabetes rates in both developed and developing countries are increasing at an alarming rate. Current medications are not adequately effective in maintaining long-term glycemic control in most patients, even when used in combination, leaving diabetics susceptible to developing life threatening and debilitating complications such as cardiovascular disease, blindness, kidney complications, and amputations. Consequently, there is a critical need for more potent pharmacotherapies with novel mechanisms of action. A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed.

Original languageEnglish (US)
Pages (from-to)125-195
Number of pages71
JournalMedicinal Research Reviews
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2009

Fingerprint

Sedentary Lifestyle
Blindness
Amputation
Developed Countries
Developing Countries
Cardiovascular Diseases
Obesity
Kidney
Drug Therapy
Injections

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

Recent and emerging anti-diabetes targets. / Mohler, Michael L.; He, Yali; Wu, Zhongzhi; Dong, Jin Hwang; Miller, Duane.

In: Medicinal Research Reviews, Vol. 29, No. 1, 01.01.2009, p. 125-195.

Research output: Contribution to journalReview article

Mohler, Michael L. ; He, Yali ; Wu, Zhongzhi ; Dong, Jin Hwang ; Miller, Duane. / Recent and emerging anti-diabetes targets. In: Medicinal Research Reviews. 2009 ; Vol. 29, No. 1. pp. 125-195.
@article{85306cb8c71143849578ab5b18369c52,
title = "Recent and emerging anti-diabetes targets",
abstract = "Diabetes is a disease that affects over 150 million people worldwide for which there are multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, diabetes rates in both developed and developing countries are increasing at an alarming rate. Current medications are not adequately effective in maintaining long-term glycemic control in most patients, even when used in combination, leaving diabetics susceptible to developing life threatening and debilitating complications such as cardiovascular disease, blindness, kidney complications, and amputations. Consequently, there is a critical need for more potent pharmacotherapies with novel mechanisms of action. A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed.",
author = "Mohler, {Michael L.} and Yali He and Zhongzhi Wu and Dong, {Jin Hwang} and Duane Miller",
year = "2009",
month = "1",
day = "1",
doi = "10.1002/med.20142",
language = "English (US)",
volume = "29",
pages = "125--195",
journal = "Medicinal Research Reviews",
issn = "0198-6325",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Recent and emerging anti-diabetes targets

AU - Mohler, Michael L.

AU - He, Yali

AU - Wu, Zhongzhi

AU - Dong, Jin Hwang

AU - Miller, Duane

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Diabetes is a disease that affects over 150 million people worldwide for which there are multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, diabetes rates in both developed and developing countries are increasing at an alarming rate. Current medications are not adequately effective in maintaining long-term glycemic control in most patients, even when used in combination, leaving diabetics susceptible to developing life threatening and debilitating complications such as cardiovascular disease, blindness, kidney complications, and amputations. Consequently, there is a critical need for more potent pharmacotherapies with novel mechanisms of action. A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed.

AB - Diabetes is a disease that affects over 150 million people worldwide for which there are multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, diabetes rates in both developed and developing countries are increasing at an alarming rate. Current medications are not adequately effective in maintaining long-term glycemic control in most patients, even when used in combination, leaving diabetics susceptible to developing life threatening and debilitating complications such as cardiovascular disease, blindness, kidney complications, and amputations. Consequently, there is a critical need for more potent pharmacotherapies with novel mechanisms of action. A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed.

UR - http://www.scopus.com/inward/record.url?scp=58849149063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849149063&partnerID=8YFLogxK

U2 - 10.1002/med.20142

DO - 10.1002/med.20142

M3 - Review article

VL - 29

SP - 125

EP - 195

JO - Medicinal Research Reviews

JF - Medicinal Research Reviews

SN - 0198-6325

IS - 1

ER -