Recent Insights on Pediatric Pseudotumor Cerebri Syndrome Pathophysiology

From the Unifying Neuroendocrine Perspective to the Integrated Bioenergetic-Hormonal Mechanism"

Vincenzo Salpietro, Martino Ruggieri, Daniela Concolino, Conrad E. Johanson, Karl Weber

Research output: Contribution to journalReview article

Abstract

Pseudotumor cerebri syndrome (PTCS) is a condition characterized by raised cerebrospinal fluid pressure in the setting of evidently normal brain parenchyma and stable composition of the cerebrospinal fluid. The pathophysiology of this syndrome is complex and not yet fully understood. Idiopathic intracranial hypertension (IIH), which is the primary (idiopathic) form of PTCS, generally affects adult obese females in their childbearing age. In children, PTCS is more commonly (compared with adults) associated with concomitant comorbidities (e.g., chronic medical conditions, endocrinopathies, treatment with tetracyclines, recombinant growth hormone, and thyroid supplementation). Together, these likely etiologic factors appear to lack a unifying pathophysiologic mechanism; however, the most recent research in this field is aiming to identify a common clue among most (if not all) secondary associations of pediatric PTCS. This has led in the last few years to a deeper understanding of the interplay among metabolic and endocrine derangements in PTCS, providing new insights into its pathophysiology.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalJournal of Pediatric Neurology
Volume13
Issue number1
DOIs
StatePublished - Mar 1 2015

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Pseudotumor Cerebri
Energy Metabolism
Pediatrics
Cerebrospinal Fluid Pressure
Tetracyclines
Growth Hormone
Cerebrospinal Fluid
Comorbidity
Thyroid Gland
Brain
Research

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Recent Insights on Pediatric Pseudotumor Cerebri Syndrome Pathophysiology : From the Unifying Neuroendocrine Perspective to the Integrated Bioenergetic-Hormonal Mechanism". / Salpietro, Vincenzo; Ruggieri, Martino; Concolino, Daniela; Johanson, Conrad E.; Weber, Karl.

In: Journal of Pediatric Neurology, Vol. 13, No. 1, 01.03.2015, p. 11-15.

Research output: Contribution to journalReview article

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abstract = "Pseudotumor cerebri syndrome (PTCS) is a condition characterized by raised cerebrospinal fluid pressure in the setting of evidently normal brain parenchyma and stable composition of the cerebrospinal fluid. The pathophysiology of this syndrome is complex and not yet fully understood. Idiopathic intracranial hypertension (IIH), which is the primary (idiopathic) form of PTCS, generally affects adult obese females in their childbearing age. In children, PTCS is more commonly (compared with adults) associated with concomitant comorbidities (e.g., chronic medical conditions, endocrinopathies, treatment with tetracyclines, recombinant growth hormone, and thyroid supplementation). Together, these likely etiologic factors appear to lack a unifying pathophysiologic mechanism; however, the most recent research in this field is aiming to identify a common clue among most (if not all) secondary associations of pediatric PTCS. This has led in the last few years to a deeper understanding of the interplay among metabolic and endocrine derangements in PTCS, providing new insights into its pathophysiology.",
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