Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

Shi Du Yan, Huaijie Zhu, Aiping Zhu, Adam Golabek, Hong Du, Alex Roher, Jin Yu, Claudio Soto, Ann Marie Schmidt, David Stern, Mark Kindy

Research output: Contribution to journalArticle

264 Citations (Scopus)

Abstract

Accumulation of fibrils composed of amyloid A in tissues resulting in displacement of normal structures and cellular dysfunction is the characteristic feature of systemic amyloidoses. Here we show that RAGE, a multiligand immunoglobulin superfamily cell surface molecule, is a receptor for the amyloidogenic form of serum amyloid A. Interactions between RAGE and amyloid A induced cellular perturbation. In a mouse model, amyloid A accumulation, evidence of cell stress and expression of RAGE were closely linked. Antagonizing RAGE suppressed cell stress and amyloid deposition in mouse spleens. These data indicate that RAGE is a potential target for inhibiting accumulation of amyloid A and for limiting cellular dysfunction induced by amyloid A.

Original languageEnglish (US)
Pages (from-to)643-651
Number of pages9
JournalNature Medicine
Volume6
Issue number6
DOIs
StatePublished - Jun 1 2000
Externally publishedYes

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Amyloidosis
Amyloid
Serum Amyloid A Protein
Cellular Structures
Immunoglobulins
Spleen
Tissue
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Yan, S. D., Zhu, H., Zhu, A., Golabek, A., Du, H., Roher, A., ... Kindy, M. (2000). Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nature Medicine, 6(6), 643-651. https://doi.org/10.1038/76216

Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. / Yan, Shi Du; Zhu, Huaijie; Zhu, Aiping; Golabek, Adam; Du, Hong; Roher, Alex; Yu, Jin; Soto, Claudio; Schmidt, Ann Marie; Stern, David; Kindy, Mark.

In: Nature Medicine, Vol. 6, No. 6, 01.06.2000, p. 643-651.

Research output: Contribution to journalArticle

Yan, SD, Zhu, H, Zhu, A, Golabek, A, Du, H, Roher, A, Yu, J, Soto, C, Schmidt, AM, Stern, D & Kindy, M 2000, 'Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis', Nature Medicine, vol. 6, no. 6, pp. 643-651. https://doi.org/10.1038/76216
Yan SD, Zhu H, Zhu A, Golabek A, Du H, Roher A et al. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nature Medicine. 2000 Jun 1;6(6):643-651. https://doi.org/10.1038/76216
Yan, Shi Du ; Zhu, Huaijie ; Zhu, Aiping ; Golabek, Adam ; Du, Hong ; Roher, Alex ; Yu, Jin ; Soto, Claudio ; Schmidt, Ann Marie ; Stern, David ; Kindy, Mark. / Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. In: Nature Medicine. 2000 ; Vol. 6, No. 6. pp. 643-651.
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