Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response

Birgit Liliensiek, Markus A. Weigand, Angelika Bierhaus, Werner Nicklas, Michael Kasper, Stefan Hofer, Jens Plachky, Herman Josef Gröne, Florian C. Kurschus, Ann Marie Schmidt, Shi Du Yan, Eike Martin, Erwin Schleicher, David Stern, Günter J. Hämmerling, Peter P. Nawroth, Bernd Arnold

Research output: Contribution to journalArticle

394 Citations (Scopus)

Abstract

While the initiation of the adaptive and innate immune response is well understood, less is known about cellular mechanisms propagating inflammation. The receptor for advanced giycation end products (RAGE), a transmembrane receptor of the immunoglobulin superfamily, leads to perpetuated cell activation. Using novel animal models with defective or tissue-specific RAGE expression, we show that in these animal models RAGE does not play a role in the adaptive immune response. However, deletion of RAGE provides protection from the lethal effects of septic shock caused by cecal ligation and puncture. Such protection is reversed by reconstitution of RAGE in endothelial and hematopoietic cells. These results indicate that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation.

Original languageEnglish (US)
Pages (from-to)1641-1650
Number of pages10
JournalJournal of Clinical Investigation
Volume113
Issue number11
DOIs
StatePublished - Jun 1 2004

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Adaptive Immunity
Sepsis
Innate Immunity
Animal Models
Pattern Recognition Receptors
Septic Shock
Punctures
Ligation
Immunoglobulins
Endothelial Cells
Inflammation
Advanced Glycosylation End Product-Specific Receptor

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Liliensiek, B., Weigand, M. A., Bierhaus, A., Nicklas, W., Kasper, M., Hofer, S., ... Arnold, B. (2004). Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. Journal of Clinical Investigation, 113(11), 1641-1650. https://doi.org/10.1172/JCI200418704

Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. / Liliensiek, Birgit; Weigand, Markus A.; Bierhaus, Angelika; Nicklas, Werner; Kasper, Michael; Hofer, Stefan; Plachky, Jens; Gröne, Herman Josef; Kurschus, Florian C.; Schmidt, Ann Marie; Yan, Shi Du; Martin, Eike; Schleicher, Erwin; Stern, David; Hämmerling, Günter J.; Nawroth, Peter P.; Arnold, Bernd.

In: Journal of Clinical Investigation, Vol. 113, No. 11, 01.06.2004, p. 1641-1650.

Research output: Contribution to journalArticle

Liliensiek, B, Weigand, MA, Bierhaus, A, Nicklas, W, Kasper, M, Hofer, S, Plachky, J, Gröne, HJ, Kurschus, FC, Schmidt, AM, Yan, SD, Martin, E, Schleicher, E, Stern, D, Hämmerling, GJ, Nawroth, PP & Arnold, B 2004, 'Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response', Journal of Clinical Investigation, vol. 113, no. 11, pp. 1641-1650. https://doi.org/10.1172/JCI200418704
Liliensiek, Birgit ; Weigand, Markus A. ; Bierhaus, Angelika ; Nicklas, Werner ; Kasper, Michael ; Hofer, Stefan ; Plachky, Jens ; Gröne, Herman Josef ; Kurschus, Florian C. ; Schmidt, Ann Marie ; Yan, Shi Du ; Martin, Eike ; Schleicher, Erwin ; Stern, David ; Hämmerling, Günter J. ; Nawroth, Peter P. ; Arnold, Bernd. / Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. In: Journal of Clinical Investigation. 2004 ; Vol. 113, No. 11. pp. 1641-1650.
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