Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells

Nigel J. Pyne, Catherine M. Waters, Jaclyn S. Long, Noreen A. Moughal, Gabor Tigyi, Susan Pyne

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We describe here formation of a novel functional signaling complex between RTK and GPCRπ. This permits the use of activated G-protein subunits by the RTK in response to growth factor and that are made available by the constitutive activity of the GPCR or by binding of ligand to the latter. Moreover, β-arrestin associates with the receptor complex and participates in growth factor-dependent recruitment of c-Src, whereupon the kinase is activated by Gβγ subunits. This enables signal relay to down-stream effectors such as p42/p44 mitogen-activated protein kinases. The novel RTK-GPCR complex is involved in regulating important cellular responses, such as growth and cell migration, and dysfunction of this complex might play a significant role in hyperplasic disease states.

Original languageEnglish (US)
Pages (from-to)271-280
Number of pages10
JournalAdvances in Enzyme Regulation
Volume47
Issue number1
DOIs
StatePublished - Jan 1 2007

Fingerprint

Receptor Protein-Tyrosine Kinases
G-Protein-Coupled Receptors
Intercellular Signaling Peptides and Proteins
Arrestin
Mitogen-Activated Protein Kinase 1
Protein Subunits
GTP-Binding Proteins
Cell Movement
Ligands
Growth
CSK tyrosine-protein kinase

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells. / Pyne, Nigel J.; Waters, Catherine M.; Long, Jaclyn S.; Moughal, Noreen A.; Tigyi, Gabor; Pyne, Susan.

In: Advances in Enzyme Regulation, Vol. 47, No. 1, 01.01.2007, p. 271-280.

Research output: Contribution to journalArticle

Pyne, Nigel J. ; Waters, Catherine M. ; Long, Jaclyn S. ; Moughal, Noreen A. ; Tigyi, Gabor ; Pyne, Susan. / Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells. In: Advances in Enzyme Regulation. 2007 ; Vol. 47, No. 1. pp. 271-280.
@article{f4d06e1b83d14dd6926f1f9bf53ddf15,
title = "Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells",
abstract = "We describe here formation of a novel functional signaling complex between RTK and GPCRπ. This permits the use of activated G-protein subunits by the RTK in response to growth factor and that are made available by the constitutive activity of the GPCR or by binding of ligand to the latter. Moreover, β-arrestin associates with the receptor complex and participates in growth factor-dependent recruitment of c-Src, whereupon the kinase is activated by Gβγ subunits. This enables signal relay to down-stream effectors such as p42/p44 mitogen-activated protein kinases. The novel RTK-GPCR complex is involved in regulating important cellular responses, such as growth and cell migration, and dysfunction of this complex might play a significant role in hyperplasic disease states.",
author = "Pyne, {Nigel J.} and Waters, {Catherine M.} and Long, {Jaclyn S.} and Moughal, {Noreen A.} and Gabor Tigyi and Susan Pyne",
year = "2007",
month = "1",
day = "1",
doi = "10.1016/j.advenzreg.2006.12.011",
language = "English (US)",
volume = "47",
pages = "271--280",
journal = "Advances in Biological Regulation",
issn = "2212-4926",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells

AU - Pyne, Nigel J.

AU - Waters, Catherine M.

AU - Long, Jaclyn S.

AU - Moughal, Noreen A.

AU - Tigyi, Gabor

AU - Pyne, Susan

PY - 2007/1/1

Y1 - 2007/1/1

N2 - We describe here formation of a novel functional signaling complex between RTK and GPCRπ. This permits the use of activated G-protein subunits by the RTK in response to growth factor and that are made available by the constitutive activity of the GPCR or by binding of ligand to the latter. Moreover, β-arrestin associates with the receptor complex and participates in growth factor-dependent recruitment of c-Src, whereupon the kinase is activated by Gβγ subunits. This enables signal relay to down-stream effectors such as p42/p44 mitogen-activated protein kinases. The novel RTK-GPCR complex is involved in regulating important cellular responses, such as growth and cell migration, and dysfunction of this complex might play a significant role in hyperplasic disease states.

AB - We describe here formation of a novel functional signaling complex between RTK and GPCRπ. This permits the use of activated G-protein subunits by the RTK in response to growth factor and that are made available by the constitutive activity of the GPCR or by binding of ligand to the latter. Moreover, β-arrestin associates with the receptor complex and participates in growth factor-dependent recruitment of c-Src, whereupon the kinase is activated by Gβγ subunits. This enables signal relay to down-stream effectors such as p42/p44 mitogen-activated protein kinases. The novel RTK-GPCR complex is involved in regulating important cellular responses, such as growth and cell migration, and dysfunction of this complex might play a significant role in hyperplasic disease states.

UR - http://www.scopus.com/inward/record.url?scp=34548120601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548120601&partnerID=8YFLogxK

U2 - 10.1016/j.advenzreg.2006.12.011

DO - 10.1016/j.advenzreg.2006.12.011

M3 - Article

VL - 47

SP - 271

EP - 280

JO - Advances in Biological Regulation

JF - Advances in Biological Regulation

SN - 2212-4926

IS - 1

ER -