Reciprocal connections between the lateral hypothalamus and the frontal cortex in the rat

Electrophysiological and anatomical observations

Hitoshi Kita, Yutaka Oomura

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Inputs to rat lateral hypothalamus (LHA) from prefrontal cortex (FC), and vice versa, were studied by intracellular recording, and by retrograde horseradish peroxidase (HRP) method. Stimulation of the FC evoked 3 types of response: a polysynaptic EPSP-IPSP sequence, IPSPs alone, or antidromic response in LHA neurons. Forty-four per cent of IPSPs were considered to be monosynaptic since the latencies were constant when stimulus intensity was changed. The neurons labeled in the FC following electrophoretic injections of HRP into LHA were located in the medial and sulcal FC. In these cortical areas, not only pyramidal neurons in layer V, but also non-pyramidal neurons in layer VI were labeled. Stimulation of the LHA evoked an EPSP-IPSP sequence, or antidromic response in FC neurons. Some of the fast EPSPs were considered to be monosynaptic. The neurons labeled in the LHA following HRP injection into the FC were either relatively large spherical neurons or small ovoid-shaped neurons. These were distributed diffusely throughout the LHA.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalBrain Research
Volume213
Issue number1
DOIs
StatePublished - May 25 1981
Externally publishedYes

Fingerprint

Lateral Hypothalamic Area
Frontal Lobe
Prefrontal Cortex
Inhibitory Postsynaptic Potentials
Neurons
Excitatory Postsynaptic Potentials
Horseradish Peroxidase
Injections
Pyramidal Cells

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Reciprocal connections between the lateral hypothalamus and the frontal cortex in the rat : Electrophysiological and anatomical observations. / Kita, Hitoshi; Oomura, Yutaka.

In: Brain Research, Vol. 213, No. 1, 25.05.1981, p. 1-16.

Research output: Contribution to journalArticle

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