Recovery of running performance following muscle-damaging exercise

Relationship to brain IL-1β

Martin D. Carmichael, J. Mark Davis, E. Angela Murphy, Adrienne S. Brown, James Carson, Eugene Mayer, Abdul Ghaffar

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Recovery following muscle-damaging downhill running is associated with increased muscle inflammatory cytokines. Various inflammatory challenges can also increase cytokines in the brain, which have been linked to sickness behaviors, including fatigue, but little is known about the brain cytokine response to stressful exercise. We used a downhill running model to determine the relationship between brain IL-1β and recovery of running performance. Male C57BL/6 mice were assigned to: downhill (DH), uphill (UH), or non-running control (Con) groups and run on a treadmill at 22 m/min and -14% or 14% grade, for 150 min. Following the run, a subset of DH and UH was placed into activity wheel cages where voluntary running activity was measured for 7 days. A second subset was run to fatigue on a motorized treadmill at 36 m/min, 8% grade at 24, 48, and 96 h post-up/downhill run. A third subset of DH, UH, and Con mice had brains dissected and assayed for IL-1β at 24 and 48 h. DH resulted in delayed recovery of both voluntary wheel-running and treadmill running to fatigue as compared to UH (p < .05). DH was also associated with increased IL-1β concentrations in cortex (at 24 and 48 h) and cerebellum (24 h) as compared to UH and Con. UH was not different than Con in any brain region. Eccentric-biased downhill running results in an increase in plasma CK and delayed recovery in running performance, as compared to the more metabolically demanding uphill running, and this was associated with increased concentrations of IL-1β in regions of the brain responsible for movement, coordination, motivation, perception of effort, and pain.

Original languageEnglish (US)
Pages (from-to)445-452
Number of pages8
JournalBrain, Behavior, and Immunity
Volume19
Issue number5
DOIs
StatePublished - Sep 1 2005
Externally publishedYes

Fingerprint

Interleukin-1
Running
Muscles
Brain
Fatigue
Cytokines
Illness Behavior
Pain Perception
Inbred C57BL Mouse
Cerebellum
Motivation
Control Groups

All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

Cite this

Recovery of running performance following muscle-damaging exercise : Relationship to brain IL-1β. / Carmichael, Martin D.; Davis, J. Mark; Murphy, E. Angela; Brown, Adrienne S.; Carson, James; Mayer, Eugene; Ghaffar, Abdul.

In: Brain, Behavior, and Immunity, Vol. 19, No. 5, 01.09.2005, p. 445-452.

Research output: Contribution to journalArticle

Carmichael, Martin D. ; Davis, J. Mark ; Murphy, E. Angela ; Brown, Adrienne S. ; Carson, James ; Mayer, Eugene ; Ghaffar, Abdul. / Recovery of running performance following muscle-damaging exercise : Relationship to brain IL-1β. In: Brain, Behavior, and Immunity. 2005 ; Vol. 19, No. 5. pp. 445-452.
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