Recreational physical activity and ovarian cancer risk in African American women

Sarah E. Abbott, Elisa V. Bandera, Bo Qin, Lauren C. Peres, Patricia G. Moorman, Jill Barnholtz-Sloan, Ann G. Schwartz, Ellen Funkhouser, Edward S. Peters, Michele L. Cote, Anthony J. Alberg, Paul Terry, Melissa Bondy, Lisa E. Paddock, Sydnee Crankshaw, Frances Wang, Fabian Camacho, Joellen M. Schildkraut

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American (AA) population. We analyzed data from an ongoing U.S. population-based, case–control study of AA women, which included 393 women recently diagnosed with invasive epithelial ovarian cancer (IEOC) and 611 controls. A baseline interview assessed RPA frequency, intensity, and duration. Each RPA intensity was assigned a metabolic equivalent of task (MET) value and MET-min/week were calculated. Unconditional multivariable logistic regression was performed to investigate associations between RPA and IEOC risk. Compared with sedentary women, predominantly mild intensity RPA was significantly inversely associated with IEOC risk for women reporting above median (>297) MET-min/week (odds ratio [OR] = 0.52; 95% confidence interval [CI]: 0.34, 0.78) and nonsignificantly for <297 MET-min/week (OR = 0.71; 95% CI: 0.44, 1.12). Predominantly moderate intensity RPA was associated with significantly increased risk for women reporting above median (>540) MET-min/week (OR = 1.51; 95% CI: 1.03, 2.23). Predominantly strenuous intensity RPA was nonsignificantly associated with lower IEOC risk for women reporting above median (>1800) MET-min/week (OR = 0.72; 95% CI: 0.33, 1.57). The inverse associations for mild and strenuous intensity RPA were most pronounced in obese women (body mass index >30 kg/m2). The findings that mild and strenuous RPA may reduce the risk of IEOC particularly among obese women are difficult to reconcile with the increased risk observed for moderate RPA. Further research is warranted to determine whether these findings are genuine and, if so, their mechanistic basis.

Original languageEnglish (US)
Pages (from-to)1319-1327
Number of pages9
JournalCancer Medicine
Volume5
Issue number6
DOIs
StatePublished - Jun 1 2016

Fingerprint

African Americans
Ovarian Neoplasms
Exercise
Metabolic Equivalent
Odds Ratio
Confidence Intervals
Population
Body Mass Index
Logistic Models
Ovarian epithelial cancer
Interviews

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Abbott, S. E., Bandera, E. V., Qin, B., Peres, L. C., Moorman, P. G., Barnholtz-Sloan, J., ... Schildkraut, J. M. (2016). Recreational physical activity and ovarian cancer risk in African American women. Cancer Medicine, 5(6), 1319-1327. https://doi.org/10.1002/cam4.677

Recreational physical activity and ovarian cancer risk in African American women. / Abbott, Sarah E.; Bandera, Elisa V.; Qin, Bo; Peres, Lauren C.; Moorman, Patricia G.; Barnholtz-Sloan, Jill; Schwartz, Ann G.; Funkhouser, Ellen; Peters, Edward S.; Cote, Michele L.; Alberg, Anthony J.; Terry, Paul; Bondy, Melissa; Paddock, Lisa E.; Crankshaw, Sydnee; Wang, Frances; Camacho, Fabian; Schildkraut, Joellen M.

In: Cancer Medicine, Vol. 5, No. 6, 01.06.2016, p. 1319-1327.

Research output: Contribution to journalArticle

Abbott, SE, Bandera, EV, Qin, B, Peres, LC, Moorman, PG, Barnholtz-Sloan, J, Schwartz, AG, Funkhouser, E, Peters, ES, Cote, ML, Alberg, AJ, Terry, P, Bondy, M, Paddock, LE, Crankshaw, S, Wang, F, Camacho, F & Schildkraut, JM 2016, 'Recreational physical activity and ovarian cancer risk in African American women', Cancer Medicine, vol. 5, no. 6, pp. 1319-1327. https://doi.org/10.1002/cam4.677
Abbott SE, Bandera EV, Qin B, Peres LC, Moorman PG, Barnholtz-Sloan J et al. Recreational physical activity and ovarian cancer risk in African American women. Cancer Medicine. 2016 Jun 1;5(6):1319-1327. https://doi.org/10.1002/cam4.677
Abbott, Sarah E. ; Bandera, Elisa V. ; Qin, Bo ; Peres, Lauren C. ; Moorman, Patricia G. ; Barnholtz-Sloan, Jill ; Schwartz, Ann G. ; Funkhouser, Ellen ; Peters, Edward S. ; Cote, Michele L. ; Alberg, Anthony J. ; Terry, Paul ; Bondy, Melissa ; Paddock, Lisa E. ; Crankshaw, Sydnee ; Wang, Frances ; Camacho, Fabian ; Schildkraut, Joellen M. / Recreational physical activity and ovarian cancer risk in African American women. In: Cancer Medicine. 2016 ; Vol. 5, No. 6. pp. 1319-1327.
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