Recreational physical activity and survival in African-American women with ovarian cancer

Sarah E. Abbott, Fabian Camacho, Lauren C. Peres, Anthony J. Alberg, Elisa V. Bandera, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Patricia G. Moorman, Edward S. Peters, Bo Qin, Ann G. Schwartz, Jill Barnholtz-Sloan, Paul Terry, Joellen M. Schildkraut

Research output: Contribution to journalArticle

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Abstract

Purpose: While recreational physical activity (RPA) has been associated with reduced mortality in breast, colorectal, and prostate cancers, evidence for epithelial ovarian cancer (EOC) is limited. Most EOC studies have been in predominantly white populations, although inactivity is more prevalent and survival is poorer among African-American (AA) women. We examined RPA before and after EOC diagnosis and associations with survival among AA women. Methods: We analyzed data from 264 EOC survivors enrolled in a population-based, case–control study who completed surveys that included questions about pre- and post-diagnosis RPA. Data were collected on RPA frequency, intensity, and duration before diagnosis and approximately 1 year after the baseline interview. We calculated metabolic equivalent of task (MET)-hours/week for pre- and post-diagnosis RPA, and evaluated associations with risk of mortality using Cox proportional hazards models. Results: RPA before diagnosis was not associated with mortality. Hazard ratios (HRs) for post-diagnosis RPA were < 1.0 but not statistically significant after adjustment for covariates; HRs were 0.94 (95% CI 0.58, 1.54) for > 0–9 MET-hours/week and 0.53 (95% CI 0.21, 1.35) for > 9 MET-hours/week. Conclusions: Our results suggest that RPA may be inversely associated with mortality among AA women with ovarian cancer, although it is possible that the present study was underpowered to detect an association. There is a clear need for more studies of RPA after diagnosis in EOC survivors with attention to potential differences by race.

Original languageEnglish (US)
Pages (from-to)77-86
Number of pages10
JournalCancer Causes and Control
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2018

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African Americans
Ovarian Neoplasms
Exercise
Survival
Metabolic Equivalent
Mortality
Survivors
Proportional Hazards Models
Population
Colorectal Neoplasms
Prostatic Neoplasms
Ovarian epithelial cancer
Interviews
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Abbott, S. E., Camacho, F., Peres, L. C., Alberg, A. J., Bandera, E. V., Bondy, M., ... Schildkraut, J. M. (2018). Recreational physical activity and survival in African-American women with ovarian cancer. Cancer Causes and Control, 29(1), 77-86. https://doi.org/10.1007/s10552-017-0986-8

Recreational physical activity and survival in African-American women with ovarian cancer. / Abbott, Sarah E.; Camacho, Fabian; Peres, Lauren C.; Alberg, Anthony J.; Bandera, Elisa V.; Bondy, Melissa; Cote, Michele L.; Funkhouser, Ellen; Moorman, Patricia G.; Peters, Edward S.; Qin, Bo; Schwartz, Ann G.; Barnholtz-Sloan, Jill; Terry, Paul; Schildkraut, Joellen M.

In: Cancer Causes and Control, Vol. 29, No. 1, 01.01.2018, p. 77-86.

Research output: Contribution to journalArticle

Abbott, SE, Camacho, F, Peres, LC, Alberg, AJ, Bandera, EV, Bondy, M, Cote, ML, Funkhouser, E, Moorman, PG, Peters, ES, Qin, B, Schwartz, AG, Barnholtz-Sloan, J, Terry, P & Schildkraut, JM 2018, 'Recreational physical activity and survival in African-American women with ovarian cancer', Cancer Causes and Control, vol. 29, no. 1, pp. 77-86. https://doi.org/10.1007/s10552-017-0986-8
Abbott, Sarah E. ; Camacho, Fabian ; Peres, Lauren C. ; Alberg, Anthony J. ; Bandera, Elisa V. ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Moorman, Patricia G. ; Peters, Edward S. ; Qin, Bo ; Schwartz, Ann G. ; Barnholtz-Sloan, Jill ; Terry, Paul ; Schildkraut, Joellen M. / Recreational physical activity and survival in African-American women with ovarian cancer. In: Cancer Causes and Control. 2018 ; Vol. 29, No. 1. pp. 77-86.
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abstract = "Purpose: While recreational physical activity (RPA) has been associated with reduced mortality in breast, colorectal, and prostate cancers, evidence for epithelial ovarian cancer (EOC) is limited. Most EOC studies have been in predominantly white populations, although inactivity is more prevalent and survival is poorer among African-American (AA) women. We examined RPA before and after EOC diagnosis and associations with survival among AA women. Methods: We analyzed data from 264 EOC survivors enrolled in a population-based, case–control study who completed surveys that included questions about pre- and post-diagnosis RPA. Data were collected on RPA frequency, intensity, and duration before diagnosis and approximately 1 year after the baseline interview. We calculated metabolic equivalent of task (MET)-hours/week for pre- and post-diagnosis RPA, and evaluated associations with risk of mortality using Cox proportional hazards models. Results: RPA before diagnosis was not associated with mortality. Hazard ratios (HRs) for post-diagnosis RPA were < 1.0 but not statistically significant after adjustment for covariates; HRs were 0.94 (95{\%} CI 0.58, 1.54) for > 0–9 MET-hours/week and 0.53 (95{\%} CI 0.21, 1.35) for > 9 MET-hours/week. Conclusions: Our results suggest that RPA may be inversely associated with mortality among AA women with ovarian cancer, although it is possible that the present study was underpowered to detect an association. There is a clear need for more studies of RPA after diagnosis in EOC survivors with attention to potential differences by race.",
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T1 - Recreational physical activity and survival in African-American women with ovarian cancer

AU - Abbott, Sarah E.

AU - Camacho, Fabian

AU - Peres, Lauren C.

AU - Alberg, Anthony J.

AU - Bandera, Elisa V.

AU - Bondy, Melissa

AU - Cote, Michele L.

AU - Funkhouser, Ellen

AU - Moorman, Patricia G.

AU - Peters, Edward S.

AU - Qin, Bo

AU - Schwartz, Ann G.

AU - Barnholtz-Sloan, Jill

AU - Terry, Paul

AU - Schildkraut, Joellen M.

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N2 - Purpose: While recreational physical activity (RPA) has been associated with reduced mortality in breast, colorectal, and prostate cancers, evidence for epithelial ovarian cancer (EOC) is limited. Most EOC studies have been in predominantly white populations, although inactivity is more prevalent and survival is poorer among African-American (AA) women. We examined RPA before and after EOC diagnosis and associations with survival among AA women. Methods: We analyzed data from 264 EOC survivors enrolled in a population-based, case–control study who completed surveys that included questions about pre- and post-diagnosis RPA. Data were collected on RPA frequency, intensity, and duration before diagnosis and approximately 1 year after the baseline interview. We calculated metabolic equivalent of task (MET)-hours/week for pre- and post-diagnosis RPA, and evaluated associations with risk of mortality using Cox proportional hazards models. Results: RPA before diagnosis was not associated with mortality. Hazard ratios (HRs) for post-diagnosis RPA were < 1.0 but not statistically significant after adjustment for covariates; HRs were 0.94 (95% CI 0.58, 1.54) for > 0–9 MET-hours/week and 0.53 (95% CI 0.21, 1.35) for > 9 MET-hours/week. Conclusions: Our results suggest that RPA may be inversely associated with mortality among AA women with ovarian cancer, although it is possible that the present study was underpowered to detect an association. There is a clear need for more studies of RPA after diagnosis in EOC survivors with attention to potential differences by race.

AB - Purpose: While recreational physical activity (RPA) has been associated with reduced mortality in breast, colorectal, and prostate cancers, evidence for epithelial ovarian cancer (EOC) is limited. Most EOC studies have been in predominantly white populations, although inactivity is more prevalent and survival is poorer among African-American (AA) women. We examined RPA before and after EOC diagnosis and associations with survival among AA women. Methods: We analyzed data from 264 EOC survivors enrolled in a population-based, case–control study who completed surveys that included questions about pre- and post-diagnosis RPA. Data were collected on RPA frequency, intensity, and duration before diagnosis and approximately 1 year after the baseline interview. We calculated metabolic equivalent of task (MET)-hours/week for pre- and post-diagnosis RPA, and evaluated associations with risk of mortality using Cox proportional hazards models. Results: RPA before diagnosis was not associated with mortality. Hazard ratios (HRs) for post-diagnosis RPA were < 1.0 but not statistically significant after adjustment for covariates; HRs were 0.94 (95% CI 0.58, 1.54) for > 0–9 MET-hours/week and 0.53 (95% CI 0.21, 1.35) for > 9 MET-hours/week. Conclusions: Our results suggest that RPA may be inversely associated with mortality among AA women with ovarian cancer, although it is possible that the present study was underpowered to detect an association. There is a clear need for more studies of RPA after diagnosis in EOC survivors with attention to potential differences by race.

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