Recruitable ACE and tissue repair in the infarcted heart

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Constitutive ACE is bound to endothelial cells where it serves to regulate circulating concentrations of Ang II that normally contribute to circulatory homeostasis. Recruitable ACE, bound to macrophage and myofibroblast cell membrane, regulates local concentrations of Ang II involved in tissue repair. De novo generation of Ang II modulates expression of TGF-β1 whose autocrine/ paracrine properties regulate collagen turnover at sites of fibrous tissue formation that appear in response to various forms of injury in diverse tissues. Persistent myofibroblasts and their ACE activity at the infarct site contribute to a sustained metabolic activity that can account for a progressive fibrosis at, and remote to, sites of MI. Activation of the circulating RAAS, with sustained elevations in plasma Ang II and aldosterone, induce a pro-inflammatory vascular phenotype of small arteries and arterioles.This further promotes the appearance of recruitable ACE bound to macrophages and myofibroblasts involved in vascular remodelling. Locally produced Ang II from these vascular sites leads to perivascular fibrosis of intramural coronary vasculature of non-infarcted myocardium. At these sites, remote to the infarct, such adverse structural remodelling by fibrous tissue eventuates in ICM, a major aetiologic factor involved in the appearance of chronic cardiac failure and contributes to its progressive nature.

Original languageEnglish (US)
Pages (from-to)295-303
Number of pages9
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume1
Issue number4
DOIs
StatePublished - Jan 1 2000

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Myofibroblasts
Blood Vessels
Fibrosis
Macrophages
Arterioles
Aldosterone
Myocardium
Homeostasis
Collagen
Endothelial Cells
Heart Failure
Arteries
Cell Membrane
Phenotype
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology

Cite this

Recruitable ACE and tissue repair in the infarcted heart. / Weber, Karl; Sun, Yao.

In: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, Vol. 1, No. 4, 01.01.2000, p. 295-303.

Research output: Contribution to journalReview article

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