Recurrent Cytogenetic Abnormalities in Intravascular Large B-Cell Lymphoma

Matthew M. Klairmont, Jinjun Cheng, Michael Martin, Joel Gradowski

Research output: Contribution to journalArticle

Abstract

Objectives Data characterizing the cytogenetic landscape of intravascular large B-cell lymphoma (ILBCL) are limited. Here, we developed a comprehensive karyotypic data set to identify recurrent cytogenetic abnormalities in ILBCL. Methods Cases of ILBCL with complete cytogenetic analysis were identified from an institutional database and the literature. The combined data were systematically reviewed for the presence of recurrent abnormalities. Results Four new cases were identified and combined with 25 karyotypes previously published in the literature. Karyotypes were uniformly complex with a median of 10 aberrations. In total, 72.4% had abnormalities involving chromosome 1, with 31.0% involving rearrangements of 1p13 or 1q21; 58.6% had abnormalities involving chromosome 6, which in almost all cases involved 6q; 34.5% had abnormalities involving chromosome 14, with 27.6% involving rearrangements of 14q32; and 55.2% had abnormalities of chromosome 18, with 37.9% harboring trisomy 18. Conclusions Recurrent cytogenetic abnormalities involving chromosomes 1, 6q, and 18 are present in greater than 50% of ILBCL.

Original languageEnglish (US)
Pages (from-to)18-26
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume150
Issue number1
DOIs
StatePublished - May 31 2018

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B-Cell Lymphoma
Chromosome Aberrations
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 1
Karyotype
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 6
Cytogenetic Analysis
Cytogenetics
Databases

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Recurrent Cytogenetic Abnormalities in Intravascular Large B-Cell Lymphoma. / Klairmont, Matthew M.; Cheng, Jinjun; Martin, Michael; Gradowski, Joel.

In: American Journal of Clinical Pathology, Vol. 150, No. 1, 31.05.2018, p. 18-26.

Research output: Contribution to journalArticle

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abstract = "Objectives Data characterizing the cytogenetic landscape of intravascular large B-cell lymphoma (ILBCL) are limited. Here, we developed a comprehensive karyotypic data set to identify recurrent cytogenetic abnormalities in ILBCL. Methods Cases of ILBCL with complete cytogenetic analysis were identified from an institutional database and the literature. The combined data were systematically reviewed for the presence of recurrent abnormalities. Results Four new cases were identified and combined with 25 karyotypes previously published in the literature. Karyotypes were uniformly complex with a median of 10 aberrations. In total, 72.4{\%} had abnormalities involving chromosome 1, with 31.0{\%} involving rearrangements of 1p13 or 1q21; 58.6{\%} had abnormalities involving chromosome 6, which in almost all cases involved 6q; 34.5{\%} had abnormalities involving chromosome 14, with 27.6{\%} involving rearrangements of 14q32; and 55.2{\%} had abnormalities of chromosome 18, with 37.9{\%} harboring trisomy 18. Conclusions Recurrent cytogenetic abnormalities involving chromosomes 1, 6q, and 18 are present in greater than 50{\%} of ILBCL.",
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N2 - Objectives Data characterizing the cytogenetic landscape of intravascular large B-cell lymphoma (ILBCL) are limited. Here, we developed a comprehensive karyotypic data set to identify recurrent cytogenetic abnormalities in ILBCL. Methods Cases of ILBCL with complete cytogenetic analysis were identified from an institutional database and the literature. The combined data were systematically reviewed for the presence of recurrent abnormalities. Results Four new cases were identified and combined with 25 karyotypes previously published in the literature. Karyotypes were uniformly complex with a median of 10 aberrations. In total, 72.4% had abnormalities involving chromosome 1, with 31.0% involving rearrangements of 1p13 or 1q21; 58.6% had abnormalities involving chromosome 6, which in almost all cases involved 6q; 34.5% had abnormalities involving chromosome 14, with 27.6% involving rearrangements of 14q32; and 55.2% had abnormalities of chromosome 18, with 37.9% harboring trisomy 18. Conclusions Recurrent cytogenetic abnormalities involving chromosomes 1, 6q, and 18 are present in greater than 50% of ILBCL.

AB - Objectives Data characterizing the cytogenetic landscape of intravascular large B-cell lymphoma (ILBCL) are limited. Here, we developed a comprehensive karyotypic data set to identify recurrent cytogenetic abnormalities in ILBCL. Methods Cases of ILBCL with complete cytogenetic analysis were identified from an institutional database and the literature. The combined data were systematically reviewed for the presence of recurrent abnormalities. Results Four new cases were identified and combined with 25 karyotypes previously published in the literature. Karyotypes were uniformly complex with a median of 10 aberrations. In total, 72.4% had abnormalities involving chromosome 1, with 31.0% involving rearrangements of 1p13 or 1q21; 58.6% had abnormalities involving chromosome 6, which in almost all cases involved 6q; 34.5% had abnormalities involving chromosome 14, with 27.6% involving rearrangements of 14q32; and 55.2% had abnormalities of chromosome 18, with 37.9% harboring trisomy 18. Conclusions Recurrent cytogenetic abnormalities involving chromosomes 1, 6q, and 18 are present in greater than 50% of ILBCL.

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