Recurrent Severe Hypoinsulinemic Hypoglycemia Responsive to Temozolomide and Bevacizumab in a Patient With Doege-Potter Syndrome

Amie A. Ogunsakin, Holly L. Hilsenbeck, David C. Portnoy, Ebenezer Nyenwe

Research output: Contribution to journalReview article

Abstract

Nonislet cell tumor hypoglycemia is rare. We highlight the diagnosis and treatment of recurrent severe hypoglycemia in a 49-year-old woman with malignant solitary fibrous tumor of the pleura (Doege-Potter syndrome). The clinical, laboratory and radiologic findings of the case are presented and a brief literature review is provided. Of note, imaging studies showed a large mass in the right hemithorax and pathology and immunehistochemical stains confirmed a malignant solitary fibrous tumor of the pleura. She was a poor surgical candidate owing to a large tumor burden. She was treated with a combination of temozolomide and bevacizumab to which she responded with resolution of hypoglycemia. The treatment of choice for hypoglycemia in patients with the Doege-Potter syndrome is surgical excision. We here report that a combination of temozolomide and bevacizumab may be a viable option in patients with inoperable disease.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalAmerican Journal of the Medical Sciences
Volume356
Issue number2
DOIs
StatePublished - Aug 1 2018

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temozolomide
Hypoglycemia
Pleural Solitary Fibrous Tumor
Tumor Burden
Coloring Agents
Pathology
Bevacizumab
Hereditary renal agenesis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Recurrent Severe Hypoinsulinemic Hypoglycemia Responsive to Temozolomide and Bevacizumab in a Patient With Doege-Potter Syndrome. / Ogunsakin, Amie A.; Hilsenbeck, Holly L.; Portnoy, David C.; Nyenwe, Ebenezer.

In: American Journal of the Medical Sciences, Vol. 356, No. 2, 01.08.2018, p. 181-184.

Research output: Contribution to journalReview article

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