Red cell distribution width is independently related to endothelial dysfunction in patients with chronic kidney disease

Yalcin Solak, Mahmut I. Yilmaz, Mutlu Saglam, Kayser Caglar, Samet Verim, Hilmi U. Unal, Mahmut Gok, Erkan Demirkaya, Abduzhappar Gaipov, Mehmet Kayrak, Hakki Cetinkaya, Tayfun Eyileten, Suleyman Turk, Abdulgaffar Vural

Research output: Contribution to journalArticle

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Abstract

Background: Red cell distribution width (RDW) is a measure of erythrocyte size variability and has been shown as an independent predictor of mortality. The aim of this article was to evaluate the association of RDW with endothelial dysfunction in patients with chronic kidney disease (CKD). METHODS:: Patients with 1 to 5 stages of CKD were included in the study. Endothelial function was assessed with flow-mediated dilatation (FMD). Estimated glomerular filtration rate (eGFR) and carotid intima media thickness (CIMT) were determined. Clinicodemographic characteristics, biochemical values, complete blood counts, ferritin, C-reactive protein (CRP) and cholesterol levels were recorded. SpearmanEs correlation was used to determine correlates of RDW. Multivariate linear regression model was used to assess independent associates of FMD. RESULTS:: Overall, 367 patients with CKD 1 to 5 were included in the study. RDW showed a significant increase from stage 1 to stage 5 CKD. Median RDW was 13.5. Patients with RDW values higher than median had significantly lower hemoglobin, eGFR and FMD values and higher CIMT and CRP values compared with patients who had RDW values below median. RDW showed a significant positive correlation with the presence of diabetes mellitus, CIMT and CRP, whereas a significant negative correlation with eGFR, ferritin and FMD. Multivariate analysis showed independent predictors of FMD as RDW, presence of diabetes, hemoglobin, eGFR, CRP, and serum albumin. CONCLUSIONS:: Multivariate regression model revealed RDW as a significant predictor of FMD independent of major confounding factors, such as diabetes, inflammation, anemia and kidney function in CKD.

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalAmerican Journal of the Medical Sciences
Volume347
Issue number2
DOIs
StatePublished - Jan 1 2014

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Erythrocyte Indices
Chronic Renal Insufficiency
Dilatation
Glomerular Filtration Rate
C-Reactive Protein
Carotid Intima-Media Thickness
Ferritins
Linear Models
Hemoglobins
Blood Cell Count
Serum Albumin
Anemia
Diabetes Mellitus
Multivariate Analysis
Erythrocytes
Cholesterol
Inflammation
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Red cell distribution width is independently related to endothelial dysfunction in patients with chronic kidney disease. / Solak, Yalcin; Yilmaz, Mahmut I.; Saglam, Mutlu; Caglar, Kayser; Verim, Samet; Unal, Hilmi U.; Gok, Mahmut; Demirkaya, Erkan; Gaipov, Abduzhappar; Kayrak, Mehmet; Cetinkaya, Hakki; Eyileten, Tayfun; Turk, Suleyman; Vural, Abdulgaffar.

In: American Journal of the Medical Sciences, Vol. 347, No. 2, 01.01.2014, p. 118-124.

Research output: Contribution to journalArticle

Solak, Y, Yilmaz, MI, Saglam, M, Caglar, K, Verim, S, Unal, HU, Gok, M, Demirkaya, E, Gaipov, A, Kayrak, M, Cetinkaya, H, Eyileten, T, Turk, S & Vural, A 2014, 'Red cell distribution width is independently related to endothelial dysfunction in patients with chronic kidney disease', American Journal of the Medical Sciences, vol. 347, no. 2, pp. 118-124. https://doi.org/10.1097/MAJ.0b013e3182996a96
Solak, Yalcin ; Yilmaz, Mahmut I. ; Saglam, Mutlu ; Caglar, Kayser ; Verim, Samet ; Unal, Hilmi U. ; Gok, Mahmut ; Demirkaya, Erkan ; Gaipov, Abduzhappar ; Kayrak, Mehmet ; Cetinkaya, Hakki ; Eyileten, Tayfun ; Turk, Suleyman ; Vural, Abdulgaffar. / Red cell distribution width is independently related to endothelial dysfunction in patients with chronic kidney disease. In: American Journal of the Medical Sciences. 2014 ; Vol. 347, No. 2. pp. 118-124.
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abstract = "Background: Red cell distribution width (RDW) is a measure of erythrocyte size variability and has been shown as an independent predictor of mortality. The aim of this article was to evaluate the association of RDW with endothelial dysfunction in patients with chronic kidney disease (CKD). METHODS:: Patients with 1 to 5 stages of CKD were included in the study. Endothelial function was assessed with flow-mediated dilatation (FMD). Estimated glomerular filtration rate (eGFR) and carotid intima media thickness (CIMT) were determined. Clinicodemographic characteristics, biochemical values, complete blood counts, ferritin, C-reactive protein (CRP) and cholesterol levels were recorded. SpearmanEs correlation was used to determine correlates of RDW. Multivariate linear regression model was used to assess independent associates of FMD. RESULTS:: Overall, 367 patients with CKD 1 to 5 were included in the study. RDW showed a significant increase from stage 1 to stage 5 CKD. Median RDW was 13.5. Patients with RDW values higher than median had significantly lower hemoglobin, eGFR and FMD values and higher CIMT and CRP values compared with patients who had RDW values below median. RDW showed a significant positive correlation with the presence of diabetes mellitus, CIMT and CRP, whereas a significant negative correlation with eGFR, ferritin and FMD. Multivariate analysis showed independent predictors of FMD as RDW, presence of diabetes, hemoglobin, eGFR, CRP, and serum albumin. CONCLUSIONS:: Multivariate regression model revealed RDW as a significant predictor of FMD independent of major confounding factors, such as diabetes, inflammation, anemia and kidney function in CKD.",
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AU - Solak, Yalcin

AU - Yilmaz, Mahmut I.

AU - Saglam, Mutlu

AU - Caglar, Kayser

AU - Verim, Samet

AU - Unal, Hilmi U.

AU - Gok, Mahmut

AU - Demirkaya, Erkan

AU - Gaipov, Abduzhappar

AU - Kayrak, Mehmet

AU - Cetinkaya, Hakki

AU - Eyileten, Tayfun

AU - Turk, Suleyman

AU - Vural, Abdulgaffar

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Red cell distribution width (RDW) is a measure of erythrocyte size variability and has been shown as an independent predictor of mortality. The aim of this article was to evaluate the association of RDW with endothelial dysfunction in patients with chronic kidney disease (CKD). METHODS:: Patients with 1 to 5 stages of CKD were included in the study. Endothelial function was assessed with flow-mediated dilatation (FMD). Estimated glomerular filtration rate (eGFR) and carotid intima media thickness (CIMT) were determined. Clinicodemographic characteristics, biochemical values, complete blood counts, ferritin, C-reactive protein (CRP) and cholesterol levels were recorded. SpearmanEs correlation was used to determine correlates of RDW. Multivariate linear regression model was used to assess independent associates of FMD. RESULTS:: Overall, 367 patients with CKD 1 to 5 were included in the study. RDW showed a significant increase from stage 1 to stage 5 CKD. Median RDW was 13.5. Patients with RDW values higher than median had significantly lower hemoglobin, eGFR and FMD values and higher CIMT and CRP values compared with patients who had RDW values below median. RDW showed a significant positive correlation with the presence of diabetes mellitus, CIMT and CRP, whereas a significant negative correlation with eGFR, ferritin and FMD. Multivariate analysis showed independent predictors of FMD as RDW, presence of diabetes, hemoglobin, eGFR, CRP, and serum albumin. CONCLUSIONS:: Multivariate regression model revealed RDW as a significant predictor of FMD independent of major confounding factors, such as diabetes, inflammation, anemia and kidney function in CKD.

AB - Background: Red cell distribution width (RDW) is a measure of erythrocyte size variability and has been shown as an independent predictor of mortality. The aim of this article was to evaluate the association of RDW with endothelial dysfunction in patients with chronic kidney disease (CKD). METHODS:: Patients with 1 to 5 stages of CKD were included in the study. Endothelial function was assessed with flow-mediated dilatation (FMD). Estimated glomerular filtration rate (eGFR) and carotid intima media thickness (CIMT) were determined. Clinicodemographic characteristics, biochemical values, complete blood counts, ferritin, C-reactive protein (CRP) and cholesterol levels were recorded. SpearmanEs correlation was used to determine correlates of RDW. Multivariate linear regression model was used to assess independent associates of FMD. RESULTS:: Overall, 367 patients with CKD 1 to 5 were included in the study. RDW showed a significant increase from stage 1 to stage 5 CKD. Median RDW was 13.5. Patients with RDW values higher than median had significantly lower hemoglobin, eGFR and FMD values and higher CIMT and CRP values compared with patients who had RDW values below median. RDW showed a significant positive correlation with the presence of diabetes mellitus, CIMT and CRP, whereas a significant negative correlation with eGFR, ferritin and FMD. Multivariate analysis showed independent predictors of FMD as RDW, presence of diabetes, hemoglobin, eGFR, CRP, and serum albumin. CONCLUSIONS:: Multivariate regression model revealed RDW as a significant predictor of FMD independent of major confounding factors, such as diabetes, inflammation, anemia and kidney function in CKD.

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JF - American Journal of the Medical Sciences

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