Reduced relative lymphocyte count in African-Americans with decompensated heart failure

Sheharyar Ali, Atta U. Shahbaz, Maeda D. Nelson, Arsalan Shirwany, Ahmad Munir, Ivan C. D'cruz, Karl Weber

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: A reduction in relative lymphocyte count (%L) has been reported in whites with heart failure that inversely correlated with jugular venous pressure thereby implicating systemic venous hypertension with splanchnic congestion. OBJECTIVES: To study whether a reduced %L (<20%) occurs in African-Americans (AA) with heart failure and to address pathophysiologic mechanisms having the potential to influence lymphocyte biology and survival, we monitored patients with or without systemic venous hypertension, hypoalbuminemia, hypovitaminosis D, and secondary hyperparathyroidism. METHODS: In 131 AA (90 men; 53 ± 12 years): 113 were hospitalized, 50 with decompensated biventricular failure (DecompHF), 24 with acute left heart failure, and 39 with heart disease, but no heart failure (HDNHF); and 18 were outpatients with compensated heart failure. At the time of admission or outpatient visit, we monitored: white blood cell count and %L; and serum albumin, 25(OH)D, and parathyroid hormone (PTH). RESULTS: White blood cell count did not differ among the groups, whereas %L was reduced only in those with DecompHF (15 ± 1%; P < 0.05) versus 25 ± 2% with left heart failure, 29 ± 1% in HDNHF, and 28 ± 3% in compensated heart failure. Serum albumin was reduced in DecompHF (2.8 ± 0.1; P < 0.05), but not in any of the other groups. Reduced 25(OH)D (<30 ng/mL), in keeping with hypovitaminosis D, was found in all AA, whereas elevated serum PTH (>65 pg/mL) was found only in those with DecompHF (123 ± 22 pg/mL). CONCLUSIONS: A relative lymphocytopenia, together with hypoalbuminemia and elevated PTH, were found only in hospitalized AA with DecompHF. These findings implicate splanchnic congestion and the enteric loss of lymphocytes and albumin with an associated secondary hyperparathyroidism.

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume337
Issue number3
DOIs
StatePublished - Jan 1 2009

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Viscera
Lymphocyte Count
African Americans
Heart Failure
Hypoalbuminemia
Lymphopenia
Secondary Hyperparathyroidism
Venous Pressure
Albumins
Neck
Lymphocytes
Hypertension

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Reduced relative lymphocyte count in African-Americans with decompensated heart failure. / Ali, Sheharyar; Shahbaz, Atta U.; Nelson, Maeda D.; Shirwany, Arsalan; Munir, Ahmad; D'cruz, Ivan C.; Weber, Karl.

In: American Journal of the Medical Sciences, Vol. 337, No. 3, 01.01.2009, p. 156-160.

Research output: Contribution to journalArticle

Ali, Sheharyar ; Shahbaz, Atta U. ; Nelson, Maeda D. ; Shirwany, Arsalan ; Munir, Ahmad ; D'cruz, Ivan C. ; Weber, Karl. / Reduced relative lymphocyte count in African-Americans with decompensated heart failure. In: American Journal of the Medical Sciences. 2009 ; Vol. 337, No. 3. pp. 156-160.
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abstract = "BACKGROUND: A reduction in relative lymphocyte count ({\%}L) has been reported in whites with heart failure that inversely correlated with jugular venous pressure thereby implicating systemic venous hypertension with splanchnic congestion. OBJECTIVES: To study whether a reduced {\%}L (<20{\%}) occurs in African-Americans (AA) with heart failure and to address pathophysiologic mechanisms having the potential to influence lymphocyte biology and survival, we monitored patients with or without systemic venous hypertension, hypoalbuminemia, hypovitaminosis D, and secondary hyperparathyroidism. METHODS: In 131 AA (90 men; 53 ± 12 years): 113 were hospitalized, 50 with decompensated biventricular failure (DecompHF), 24 with acute left heart failure, and 39 with heart disease, but no heart failure (HDNHF); and 18 were outpatients with compensated heart failure. At the time of admission or outpatient visit, we monitored: white blood cell count and {\%}L; and serum albumin, 25(OH)D, and parathyroid hormone (PTH). RESULTS: White blood cell count did not differ among the groups, whereas {\%}L was reduced only in those with DecompHF (15 ± 1{\%}; P < 0.05) versus 25 ± 2{\%} with left heart failure, 29 ± 1{\%} in HDNHF, and 28 ± 3{\%} in compensated heart failure. Serum albumin was reduced in DecompHF (2.8 ± 0.1; P < 0.05), but not in any of the other groups. Reduced 25(OH)D (<30 ng/mL), in keeping with hypovitaminosis D, was found in all AA, whereas elevated serum PTH (>65 pg/mL) was found only in those with DecompHF (123 ± 22 pg/mL). CONCLUSIONS: A relative lymphocytopenia, together with hypoalbuminemia and elevated PTH, were found only in hospitalized AA with DecompHF. These findings implicate splanchnic congestion and the enteric loss of lymphocytes and albumin with an associated secondary hyperparathyroidism.",
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AU - Ali, Sheharyar

AU - Shahbaz, Atta U.

AU - Nelson, Maeda D.

AU - Shirwany, Arsalan

AU - Munir, Ahmad

AU - D'cruz, Ivan C.

AU - Weber, Karl

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N2 - BACKGROUND: A reduction in relative lymphocyte count (%L) has been reported in whites with heart failure that inversely correlated with jugular venous pressure thereby implicating systemic venous hypertension with splanchnic congestion. OBJECTIVES: To study whether a reduced %L (<20%) occurs in African-Americans (AA) with heart failure and to address pathophysiologic mechanisms having the potential to influence lymphocyte biology and survival, we monitored patients with or without systemic venous hypertension, hypoalbuminemia, hypovitaminosis D, and secondary hyperparathyroidism. METHODS: In 131 AA (90 men; 53 ± 12 years): 113 were hospitalized, 50 with decompensated biventricular failure (DecompHF), 24 with acute left heart failure, and 39 with heart disease, but no heart failure (HDNHF); and 18 were outpatients with compensated heart failure. At the time of admission or outpatient visit, we monitored: white blood cell count and %L; and serum albumin, 25(OH)D, and parathyroid hormone (PTH). RESULTS: White blood cell count did not differ among the groups, whereas %L was reduced only in those with DecompHF (15 ± 1%; P < 0.05) versus 25 ± 2% with left heart failure, 29 ± 1% in HDNHF, and 28 ± 3% in compensated heart failure. Serum albumin was reduced in DecompHF (2.8 ± 0.1; P < 0.05), but not in any of the other groups. Reduced 25(OH)D (<30 ng/mL), in keeping with hypovitaminosis D, was found in all AA, whereas elevated serum PTH (>65 pg/mL) was found only in those with DecompHF (123 ± 22 pg/mL). CONCLUSIONS: A relative lymphocytopenia, together with hypoalbuminemia and elevated PTH, were found only in hospitalized AA with DecompHF. These findings implicate splanchnic congestion and the enteric loss of lymphocytes and albumin with an associated secondary hyperparathyroidism.

AB - BACKGROUND: A reduction in relative lymphocyte count (%L) has been reported in whites with heart failure that inversely correlated with jugular venous pressure thereby implicating systemic venous hypertension with splanchnic congestion. OBJECTIVES: To study whether a reduced %L (<20%) occurs in African-Americans (AA) with heart failure and to address pathophysiologic mechanisms having the potential to influence lymphocyte biology and survival, we monitored patients with or without systemic venous hypertension, hypoalbuminemia, hypovitaminosis D, and secondary hyperparathyroidism. METHODS: In 131 AA (90 men; 53 ± 12 years): 113 were hospitalized, 50 with decompensated biventricular failure (DecompHF), 24 with acute left heart failure, and 39 with heart disease, but no heart failure (HDNHF); and 18 were outpatients with compensated heart failure. At the time of admission or outpatient visit, we monitored: white blood cell count and %L; and serum albumin, 25(OH)D, and parathyroid hormone (PTH). RESULTS: White blood cell count did not differ among the groups, whereas %L was reduced only in those with DecompHF (15 ± 1%; P < 0.05) versus 25 ± 2% with left heart failure, 29 ± 1% in HDNHF, and 28 ± 3% in compensated heart failure. Serum albumin was reduced in DecompHF (2.8 ± 0.1; P < 0.05), but not in any of the other groups. Reduced 25(OH)D (<30 ng/mL), in keeping with hypovitaminosis D, was found in all AA, whereas elevated serum PTH (>65 pg/mL) was found only in those with DecompHF (123 ± 22 pg/mL). CONCLUSIONS: A relative lymphocytopenia, together with hypoalbuminemia and elevated PTH, were found only in hospitalized AA with DecompHF. These findings implicate splanchnic congestion and the enteric loss of lymphocytes and albumin with an associated secondary hyperparathyroidism.

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