Reduction pneumoplasty-quantifying dead space & V̇A/Q̇ relationship

Aubyn Marath, S. Turnage, J. Räsänen, D. Thrush, R. Smith, D. Solomon, Peter Mckeown, M. Hodges, C. Jackson, P. Preece

Research output: Contribution to journalArticle

Abstract

Purpose: We sought to determine whether reduction in dead space and improved V̇A/Q̇ relationships after performing the surgical procedure, bilateral reduction pneumoplasty, could be quantified by Multiple Inert Gas Elimination Technique analySIS (MIGET). Methods: Eight patients, submitted for pneumoplasty, underwent systemic and pulmonary artery and peripheral vein catheters placement preoperatively. Pre- and post-operatively, an injection of a solution of 6 inert gases infused into a peripheral vein was given, followed by breathing through a mouth-piece attached to a non-rebreathing valve with the nose pinched. Expired gas was directed through a Wright respirometer for measurement of minute ventilation and collected. Systemic and pulmonary artery blood were sampled simultaneously, assayed for inert gas concentrations by gas chromatography, and blood-gas partition coefficient for each inert gas determined, with separate sampling for evaluation of respiratory gas tensions, pH, hemoglobin content, and oxyhemoglobin saturation. Simultaneous mixed expired gas sampling was then assayed for inert gas tensions and respiratory gas tensions. Physiological dead space was determined with the Enghoff-Bohr equation. Data are summarized as mean±SD and were compared with Student's t test. Results: There were no differences in minute ventilation (8.3±1.6 L/min), cardiac output (5.8±1.9 L/min), FIO 2 (0.24±0.03), PaO 2 (81±14 mmHg), or PaCO 2 (48±7 mmHg), thus pre- and post-operative data were pooled for summary. Physiological dead space was reduced from 349±83 to 285±52 mL (p=0.12). Conclusion: Although the decrease in physiological dead space and distribution of ventilation to unperfused alveoli were not significant, there appears to be a trend, which may become better identified with longer follow-up and/or staged thoracotomy procedures.

Original languageEnglish (US)
JournalChest
Volume110
Issue number4 SUPPL.
StatePublished - Oct 1 1996

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Noble Gases
Gases
Ventilation
Pulmonary Artery
Veins
Oxyhemoglobins
Thoracotomy
Nose
Cardiac Output
Gas Chromatography
Mouth
Respiration
Hemoglobins
Catheters
Students
Injections

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Marath, A., Turnage, S., Räsänen, J., Thrush, D., Smith, R., Solomon, D., ... Preece, P. (1996). Reduction pneumoplasty-quantifying dead space & V̇A/Q̇ relationship. Chest, 110(4 SUPPL.).

Reduction pneumoplasty-quantifying dead space & V̇A/Q̇ relationship. / Marath, Aubyn; Turnage, S.; Räsänen, J.; Thrush, D.; Smith, R.; Solomon, D.; Mckeown, Peter; Hodges, M.; Jackson, C.; Preece, P.

In: Chest, Vol. 110, No. 4 SUPPL., 01.10.1996.

Research output: Contribution to journalArticle

Marath, A, Turnage, S, Räsänen, J, Thrush, D, Smith, R, Solomon, D, Mckeown, P, Hodges, M, Jackson, C & Preece, P 1996, 'Reduction pneumoplasty-quantifying dead space & V̇A/Q̇ relationship', Chest, vol. 110, no. 4 SUPPL..
Marath A, Turnage S, Räsänen J, Thrush D, Smith R, Solomon D et al. Reduction pneumoplasty-quantifying dead space & V̇A/Q̇ relationship. Chest. 1996 Oct 1;110(4 SUPPL.).
Marath, Aubyn ; Turnage, S. ; Räsänen, J. ; Thrush, D. ; Smith, R. ; Solomon, D. ; Mckeown, Peter ; Hodges, M. ; Jackson, C. ; Preece, P. / Reduction pneumoplasty-quantifying dead space & V̇A/Q̇ relationship. In: Chest. 1996 ; Vol. 110, No. 4 SUPPL.
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abstract = "Purpose: We sought to determine whether reduction in dead space and improved V̇A/Q̇ relationships after performing the surgical procedure, bilateral reduction pneumoplasty, could be quantified by Multiple Inert Gas Elimination Technique analySIS (MIGET). Methods: Eight patients, submitted for pneumoplasty, underwent systemic and pulmonary artery and peripheral vein catheters placement preoperatively. Pre- and post-operatively, an injection of a solution of 6 inert gases infused into a peripheral vein was given, followed by breathing through a mouth-piece attached to a non-rebreathing valve with the nose pinched. Expired gas was directed through a Wright respirometer for measurement of minute ventilation and collected. Systemic and pulmonary artery blood were sampled simultaneously, assayed for inert gas concentrations by gas chromatography, and blood-gas partition coefficient for each inert gas determined, with separate sampling for evaluation of respiratory gas tensions, pH, hemoglobin content, and oxyhemoglobin saturation. Simultaneous mixed expired gas sampling was then assayed for inert gas tensions and respiratory gas tensions. Physiological dead space was determined with the Enghoff-Bohr equation. Data are summarized as mean±SD and were compared with Student's t test. Results: There were no differences in minute ventilation (8.3±1.6 L/min), cardiac output (5.8±1.9 L/min), FIO 2 (0.24±0.03), PaO 2 (81±14 mmHg), or PaCO 2 (48±7 mmHg), thus pre- and post-operative data were pooled for summary. Physiological dead space was reduced from 349±83 to 285±52 mL (p=0.12). Conclusion: Although the decrease in physiological dead space and distribution of ventilation to unperfused alveoli were not significant, there appears to be a trend, which may become better identified with longer follow-up and/or staged thoracotomy procedures.",
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AU - Marath, Aubyn

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AU - Smith, R.

AU - Solomon, D.

AU - Mckeown, Peter

AU - Hodges, M.

AU - Jackson, C.

AU - Preece, P.

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