Reevaluation of area 3b in the cat based on architectonic and electrophysiological studies

Regional variability with functional and anatomical consistencies

S. S. Leclerc, C. Avendaño, R. W. Dykes, Robert Waters, I. Salimi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Most anatomical and electrophysiological studies of the cat primary somatosensory cortex rely on Hassler and Muhs‐Clement's (J. Hirnforsch. 6:377‐420, 1964) cyto‐ and myeloarchitectonic description distinguishing area 3a from area 3b; however, discrepancies in the delineation of these areas in published studies suggest that many workers have found it difficult to apply those criteria systematically. We examined the cytoarchitecture of area 3b in Nissl stained sagittal sections from which electrophysiological data had been obtained prior to sacrifice. Rostrocaudal rows of electrode penetrations placed at different mediolateral positions in the gyrus located regions responsive to stimulation of either cutaneous or deep structures. Small electrolytic lesions allowed these data to be related to the cytoarchitecture. A systematic study throughout the trunk and limb representations found cutaneous responses in cortical regions characterized by a thick and cell‐dense granular layer IV, however these same regions had a variable population of medium‐sized and/or large pyramidal cells in layer V. Pyramidal cells were practically absent from the forelimb representation, but were present to varying degrees in the trunk and hindlimb representations. Moreover, the relative thickness and cell‐density in layer IV were greater in the forelimb than in the hindlimb representations. Deep responses were found in cortex characterized by a thinner layer IV. Since the characteristics of layer V in area 3a were variable, it was less useful for identification of the border between areas 3a and 3b. Clear changes in the intensity and laminar distribution of acetylcholinesterase staining occurred between areas 3a and 3b, making this a useful adjunct to the Nissl stain.

Original languageEnglish (US)
Pages (from-to)357-374
Number of pages18
JournalJournal of Comparative Neurology
Volume341
Issue number3
DOIs
StatePublished - Jan 1 1994

Fingerprint

Forelimb
Pyramidal Cells
Hindlimb
Cats
Skin
Somatosensory Cortex
Acetylcholinesterase
Electrodes
Coloring Agents
Extremities
Staining and Labeling
Population

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Reevaluation of area 3b in the cat based on architectonic and electrophysiological studies : Regional variability with functional and anatomical consistencies. / Leclerc, S. S.; Avendaño, C.; Dykes, R. W.; Waters, Robert; Salimi, I.

In: Journal of Comparative Neurology, Vol. 341, No. 3, 01.01.1994, p. 357-374.

Research output: Contribution to journalArticle

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