Refractory dilated cardiomyopathy associated with metastatic neuroblastoma

Peter Carlson, John Jefferies, Debra Kearney, Heidi Russell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 2-year-old African American male presented with heart failure and an abdominal mass. Computerized tomography (CT) scan revealed a 7 cm adrenal lesion, confirmed as poorly differentiated neuroblastoma (NB). CT and meta-iodobenzoguanidine (MIBG) scans identified multiple metastases, but cardiac MIBG imaging was absent. Cardiac ejection fraction (EF) was 8% with 7% shortening fraction. The patient underwent six cycles of chemotherapy and investigational immunotherapy. Cardiac function improved to 26% EF. However, the tumor proved unresponsive to treatment. The patient died from stage IV congestive heart failure (CHF) and progressive NB. Autopsy confirmed dilated cardiomyopathy with endocardial fibroelastosis. Pediatr Blood Cancer.

Original languageEnglish (US)
Pages (from-to)736-738
Number of pages3
JournalPediatric Blood and Cancer
Volume55
Issue number4
DOIs
StatePublished - Oct 1 2010

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Dilated Cardiomyopathy
Neuroblastoma
Heart Failure
Endocardial Fibroelastosis
Tomography
African Americans
Immunotherapy
Autopsy
Neoplasms
Neoplasm Metastasis
Drug Therapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. / Carlson, Peter; Jefferies, John; Kearney, Debra; Russell, Heidi.

In: Pediatric Blood and Cancer, Vol. 55, No. 4, 01.10.2010, p. 736-738.

Research output: Contribution to journalArticle

Carlson, Peter ; Jefferies, John ; Kearney, Debra ; Russell, Heidi. / Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. In: Pediatric Blood and Cancer. 2010 ; Vol. 55, No. 4. pp. 736-738.
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